IRF8 Antibody (PACO09992)
- SKU:
- PACO09992
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | IRF8 Antibody (PACO09992) |
抗体コード: | PACO09992 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse |
免疫原: | Human IRF8 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | interferon regulatory factor 8;IRF8;H-ICSBP;ICSBP;ICSBP1;IRF-8 ; |
UniProt Protein Function: | IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: nucleoplasm; cytosol Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; protein binding Biological Process: transcription from RNA polymerase II promoter; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; defense response to bacterium; myeloid cell differentiation; immune response; negative regulation of transcription from RNA polymerase II promoter; defense response to protozoan; phagocytosis Disease: Monocyte And Dendritic Cell Deficiency, Autosomal Recessive; Immunodeficiency 32a |
NCBI Summary: | Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q02556 |
NCBI GenInfo Identifier: | 6016308 |
NCBI Gene ID: | 3394 |
NCBI Accession: | Q02556.2 |
UniProt Secondary Accession: | Q02556,A0AV82, |
UniProt Related Accession: | Q02556 |
Molecular Weight: | Calculated MW: 48kDaObserved MW: 53kDa |
NCBI Full Name: | Interferon regulatory factor 8 |
NCBI Synonym Full Names: | interferon regulatory factor 8 |
NCBI Official Symbol: | IRF8 |
NCBI Official Synonym Symbols: | ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP |
NCBI Protein Information: | interferon regulatory factor 8; interferon consensus sequence binding protein 1 |
UniProt Protein Name: | Interferon regulatory factor 8 |
UniProt Synonym Protein Names: | Interferon consensus sequence-binding protein; H-ICSBP; ICSBP |
Protein Family: | Interferon regulatory factor |
UniProt Gene Name: | IRF8 |
UniProt Entry Name: | IRF8_HUMAN |