IREB2 Antibody (PACO51658)
- SKU:
- PACO51658
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | IREB2 Antibody (PACO51658) |
抗体コード: | PACO51658 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Iron-responsive element-binding protein 2 protein (107-216AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate, Jurkat whole cell lysate, Mouse stomach tissue. All lanes: IREB2 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 106, 38 kDa. Observed band size: 106 kDa.. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO51658 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human heart tissue using PACO51658 at dilution of 1:100. |
バックグラウンド: | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid, synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. |
シノニム: | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2), IREB2 |
UniProt Protein Function: | IREB2: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. Belongs to the aconitase/IPM isomerase family. |
UniProt Protein Details: | Protein type:RNA-binding; Translation Chromosomal Location of Human Ortholog: 15q25.1 Cellular Component: mitochondrion; cytoplasm; cytosol Molecular Function:protein binding; iron-responsive element binding; translation repressor activity; RNA binding; metal ion binding; 4 iron, 4 sulfur cluster binding Biological Process: erythrocyte homeostasis; response to retinoic acid; cellular iron ion homeostasis; negative regulation of translation; osteoclast differentiation; response to iron(II) ion; iron ion transport; protoporphyrinogen IX biosynthetic process; aging; intestinal absorption; post-embryonic development |
UniProt Code: | P48200 |
NCBI GenInfo Identifier: | 308153591 |
NCBI Gene ID: | 3658 |
NCBI Accession: | P48200.3 |
UniProt Secondary Accession: | P48200,Q13095, Q1HE21, Q59FQ7, Q8WVK6, Q9UF17, A8KAC7 E1CJT9, H0YKU0, |
UniProt Related Accession: | P48200 |
Molecular Weight: | 963 |
NCBI Full Name: | Iron-responsive element-binding protein 2 |
NCBI Synonym Full Names: | iron-responsive element binding protein 2 |
NCBI Official Symbol: | IREB2 |
NCBI Official Synonym Symbols: | ACO3; IRP2; IRP2AD |
NCBI Protein Information: | iron-responsive element-binding protein 2; IRE-BP 2; iron regulatory protein 2 |
UniProt Protein Name: | Iron-responsive element-binding protein 2 |
UniProt Synonym Protein Names: | Iron regulatory protein 2; IRP2 |
Protein Family: | Iron-responsive element-binding protein |
UniProt Gene Name: | IREB2 |
UniProt Entry Name: | IREB2_HUMAN |
Antibodies | ELISA Kits |
Anti-IREB2 Antibody (CAB6382) | Human IREB2 ELISA Kit |
Human Iron-responsive element-binding protein 2 (IREB2) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |