IREB2 Antibody, FITC conjugated (PACO51660)
- SKU:
- PACO51660
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | IREB2 Antibody, FITC conjugated (PACO51660) |
抗体コード: | PACO51660 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Iron-responsive element-binding protein 2 protein (107-216AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid, synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. |
シノニム: | Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2), IREB2 |
UniProt Protein Function: | IREB2: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. Belongs to the aconitase/IPM isomerase family. |
UniProt Protein Details: | Protein type:RNA-binding; Translation Chromosomal Location of Human Ortholog: 15q25.1 Cellular Component: mitochondrion; cytoplasm; cytosol Molecular Function:protein binding; iron-responsive element binding; translation repressor activity; RNA binding; metal ion binding; 4 iron, 4 sulfur cluster binding Biological Process: erythrocyte homeostasis; response to retinoic acid; cellular iron ion homeostasis; negative regulation of translation; osteoclast differentiation; response to iron(II) ion; iron ion transport; protoporphyrinogen IX biosynthetic process; aging; intestinal absorption; post-embryonic development |
UniProt Code: | P48200 |
NCBI GenInfo Identifier: | 308153591 |
NCBI Gene ID: | 3658 |
NCBI Accession: | P48200.3 |
UniProt Secondary Accession: | P48200,Q13095, Q1HE21, Q59FQ7, Q8WVK6, Q9UF17, A8KAC7 E1CJT9, H0YKU0, |
UniProt Related Accession: | P48200 |
Molecular Weight: | 963 |
NCBI Full Name: | Iron-responsive element-binding protein 2 |
NCBI Synonym Full Names: | iron-responsive element binding protein 2 |
NCBI Official Symbol: | IREB2 |
NCBI Official Synonym Symbols: | ACO3; IRP2; IRP2AD |
NCBI Protein Information: | iron-responsive element-binding protein 2; IRE-BP 2; iron regulatory protein 2 |
UniProt Protein Name: | Iron-responsive element-binding protein 2 |
UniProt Synonym Protein Names: | Iron regulatory protein 2; IRP2 |
Protein Family: | Iron-responsive element-binding protein |
UniProt Gene Name: | IREB2 |
UniProt Entry Name: | IREB2_HUMAN |