HPRT1 Antibody (PACO33644)
- SKU:
- PACO33644
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | HPRT1 Antibody (PACO33644) |
抗体コード: | PACO33644 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:10-1:100 |
反応性: | Human |
免疫原: | Recombinant Human Hypoxanthine-guanine phosphoribosyltransferase protein (2-218AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO33644 at dilution of 1:20. |
バックグラウンド: | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
シノニム: | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8), HPRT1, HPRT |
UniProt Protein Function: | HPRT1: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS). LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation. Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT); also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia. Belongs to the purine/pyrimidine phosphoribosyltransferase family. |
UniProt Protein Details: | Protein type:EC 2.4.2.8; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; Nucleotide Metabolism - purine; Cell development/differentiation Chromosomal Location of Human Ortholog: Xq26.1 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; protein homodimerization activity; hypoxanthine phosphoribosyltransferase activity; magnesium ion binding; nucleotide binding Biological Process: grooming behavior; lymphocyte proliferation; hypoxanthine metabolic process; IMP salvage; striatum development; nucleobase, nucleoside and nucleotide metabolic process; GMP salvage; dendrite morphogenesis; cytolysis; response to amphetamine; locomotory behavior; adenine salvage; purine nucleotide biosynthetic process; dopamine metabolic process; purine base metabolic process; purine salvage; cerebral cortex neuron differentiation; protein homotetramerization; positive regulation of dopamine metabolic process; GMP catabolic process; IMP metabolic process; hypoxanthine salvage; purine ribonucleoside salvage; central nervous system neuron development; guanine salvage Disease: Kelley-seegmiller Syndrome; Lesch-nyhan Syndrome |
NCBI Summary: | The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009] |
UniProt Code: | P00492 |
NCBI GenInfo Identifier: | 123497 |
NCBI Gene ID: | 3251 |
NCBI Accession: | P00492.2 |
UniProt Secondary Accession: | P00492,A6NHF0, B2R8M9, |
UniProt Related Accession: | P00492 |
Molecular Weight: | 218 |
NCBI Full Name: | Hypoxanthine-guanine phosphoribosyltransferase |
NCBI Synonym Full Names: | hypoxanthine phosphoribosyltransferase 1 |
NCBI Official Symbol: | HPRT1 |
NCBI Official Synonym Symbols: | HPRT; HGPRT |
NCBI Protein Information: | hypoxanthine-guanine phosphoribosyltransferase; HGPRTase |
UniProt Protein Name: | Hypoxanthine-guanine phosphoribosyltransferase |
Protein Family: | Hypoxanthine-guanine phosphoribosyltransferase |
UniProt Gene Name: | HPRT1 |
UniProt Entry Name: | HPRT_HUMAN |
Antibodies |
Anti-HPRT1 Antibody (CAB5692)[KO Validated] |
Anti-HPRT Antibody (CAB8783) |
HPRT1 Antibody (PACO09788) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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