GDF2 Antibody, Biotin conjugated (PACO42501)
- SKU:
- PACO42501
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | GDF2 Antibody, Biotin conjugated (PACO42501) |
抗体コード: | PACO42501 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Growth/differentiation factor 2 protein (300-429AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-β coreceptor endoglin/ENG. |
シノニム: | Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9), GDF2, BMP9 |
UniProt Protein Function: | GDF2: Could be involved in bone formation. Belongs to the TGF-beta family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q11.22 Cellular Component: extracellular space Molecular Function:cytokine activity; protein binding; transforming growth factor beta receptor binding Biological Process: activin receptor signaling pathway; angiogenesis; blood vessel morphogenesis; BMP signaling pathway; cartilage development; cell development; cellular iron ion homeostasis; negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell growth; negative regulation of DNA replication; negative regulation of endothelial cell proliferation; ossification; patterning of blood vessels; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of interleukin-8 production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade Disease: Telangiectasia, Hereditary Hemorrhagic, Type 5 |
NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jul 2016] |
UniProt Code: | Q9UK05 |
NCBI GenInfo Identifier: | 13124266 |
NCBI Gene ID: | 2658 |
NCBI Accession: | Q9UK05.1 |
UniProt Secondary Accession: | Q9UK05,Q5VSQ9, Q9Y571, |
UniProt Related Accession: | Q9UK05 |
Molecular Weight: | 47kDa |
NCBI Full Name: | Growth/differentiation factor 2 |
NCBI Synonym Full Names: | growth differentiation factor 2 |
NCBI Official Symbol: | GDF2 |
NCBI Official Synonym Symbols: | BMP9; HHT5; BMP-9 |
NCBI Protein Information: | growth/differentiation factor 2 |
UniProt Protein Name: | Growth/differentiation factor 2 |
UniProt Synonym Protein Names: | Bone morphogenetic protein 9; BMP-9 |
Protein Family: | Growth/differentiation factor |
UniProt Gene Name: | GDF2 |