FBXW7 Antibody, FITC conjugated (PACO52552)
- SKU:
- PACO52552
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | FBXW7 Antibody, FITC conjugated (PACO52552) |
抗体コード: | PACO52552 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human F-box/WD repeat-containing protein 7 protein (1-707AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. |
シノニム: | F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4), FBXW7, FBW7 FBX30 SEL10 |
UniProt Code: | Q969H0 |
NCBI GenInfo Identifier: | 44887885 |
NCBI Gene ID: | 55294 |
NCBI Accession: | Q969H0.1 |
UniProt Secondary Accession: | Q969H0,Q68DR0, Q96A16, Q96LE0, Q96RI2, Q9NUX6, B7ZLP9 |
UniProt Related Accession: | Q969H0 |
Molecular Weight: | 707 |
NCBI Full Name: | F-box/WD repeat-containing protein 7 |
NCBI Synonym Full Names: | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
NCBI Official Symbol: | FBXW7 |
NCBI Official Synonym Symbols: | AGO; CDC4; FBW6; FBW7; hAgo; FBX30; FBXW6; SEL10; hCdc4; FBXO30; SEL-10 |
NCBI Protein Information: | F-box/WD repeat-containing protein 7; archipelago; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; homolog of C elegans sel-10; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) |
UniProt Protein Name: | F-box/WD repeat-containing protein 7 |
UniProt Synonym Protein Names: | Archipelago homolog; hAgo; F-box and WD-40 domain-containing protein 7; F-box protein FBX30; SEL-10; hCdc4 |
Protein Family: | Cdc42 |
UniProt Gene Name: | FBXW7 |
UniProt Entry Name: | FBXW7_HUMAN |