ENO3 Antibody (PACO33304)
- SKU:
- PACO33304
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ENO3 Antibody (PACO33304) |
抗体コード: | PACO33304 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Beta-enolase protein (7-432AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO33304 at dilution of 1:100. | |
Immunofluorescent analysis of Hela cells using PACO33304 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Appears to have a function in striated muscle development and regeneration. |
シノニム: | Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase), ENO3 |
UniProt Protein Function: | ENO3: Appears to have a function in striated muscle development and regeneration. Defects in ENO3 are the cause of glycogen storage disease type 13 (GSD13). A metabolic disorder that results in exercise-induced myalgias, generalized muscle weakness and fatigability. It is characterized by increased serum creatine kinase and decreased enolase 3 activity. Dramatically reduced protein levels with focal sarcoplasmic accumulation of glycogen- beta particles are detected on ultrastructural analysis. Belongs to the enolase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lyase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11 Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: extracellular space; phosphopyruvate hydratase complex; cytoplasm; plasma membrane; cytosol Molecular Function:protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; phosphopyruvate hydratase activity Biological Process: response to drug; glycolysis; carbohydrate metabolic process; skeletal muscle regeneration; glucose metabolic process; pathogenesis; gluconeogenesis; aging Disease: Glycogen Storage Disease Xiii |
NCBI Summary: | This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010] |
UniProt Code: | P13929 |
NCBI GenInfo Identifier: | 425906077 |
NCBI Gene ID: | 2027 |
NCBI Accession: | P13929.5 |
UniProt Related Accession: | P13929 |
Molecular Weight: | |
NCBI Full Name: | Beta-enolase |
NCBI Synonym Full Names: | enolase 3 |
NCBI Official Symbol: | ENO3 |
NCBI Official Synonym Symbols: | MSE; GSD13 |
NCBI Protein Information: | beta-enolase |
UniProt Protein Name: | Beta-enolase |
UniProt Synonym Protein Names: | 2-phospho-D-glycerate hydro-lyase; Enolase 3; Muscle-specific enolase; MSE; Skeletal muscle enolase |
Protein Family: | Enolase |
UniProt Gene Name: | ENO3 |
UniProt Entry Name: | ENOB_HUMAN |