ENO3 Antibody (PACO21552)
- SKU:
- PACO21552
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ENO3 Antibody (PACO21552) |
抗体コード: | PACO21552 |
サイズ: | 100ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | Peptide sequence around aa.49~53(L-R-D-G-D) derived from Human b-Enolase(ENO-3). |
憲法: | Liquid |
ストレージバッファ: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from 3T3, HepG2 and C2C12 cells using b-Enolase(ENO-3) Antibody. |
バックグラウンド: | Appears to have a function in striated muscle development and regeneration. |
シノニム: | MSE; GSD13; |
UniProt Protein Function: | ENO3: Appears to have a function in striated muscle development and regeneration. Defects in ENO3 are the cause of glycogen storage disease type 13 (GSD13). A metabolic disorder that results in exercise-induced myalgias, generalized muscle weakness and fatigability. It is characterized by increased serum creatine kinase and decreased enolase 3 activity. Dramatically reduced protein levels with focal sarcoplasmic accumulation of glycogen- beta particles are detected on ultrastructural analysis. Belongs to the enolase family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Lyase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11 Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: extracellular space; phosphopyruvate hydratase complex; cytoplasm; plasma membrane; cytosol Molecular Function:protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; phosphopyruvate hydratase activity Biological Process: response to drug; glycolysis; carbohydrate metabolic process; skeletal muscle regeneration; glucose metabolic process; pathogenesis; gluconeogenesis; aging Disease: Glycogen Storage Disease Xiii |
NCBI Summary: | This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010] |
UniProt Code: | P13929 |
NCBI GenInfo Identifier: | 425906077 |
NCBI Gene ID: | 2027 |
NCBI Accession: | P13929.5 |
UniProt Related Accession: | P13929 |
Molecular Weight: | |
NCBI Full Name: | Beta-enolase |
NCBI Synonym Full Names: | enolase 3 |
NCBI Official Symbol: | ENO3 |
NCBI Official Synonym Symbols: | MSE; GSD13 |
NCBI Protein Information: | beta-enolase |
UniProt Protein Name: | Beta-enolase |
UniProt Synonym Protein Names: | 2-phospho-D-glycerate hydro-lyase; Enolase 3; Muscle-specific enolase; MSE; Skeletal muscle enolase |
Protein Family: | Enolase |
UniProt Gene Name: | ENO3 |
UniProt Entry Name: | ENOB_HUMAN |