DPYD Antibody, FITC conjugated (PACO48604)
- SKU:
- PACO48604
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | DPYD Antibody, FITC conjugated (PACO48604) |
抗体コード: | PACO48604 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Dihydropyrimidine dehydrogenase [NADP(+)] protein (5-152AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. |
シノニム: | Dihydropyrimidine dehydrogenase [NADP(+)] (DHPDHase) (DPD) (EC 1.3.1.2) (Dihydrothymine dehydrogenase) (Dihydrouracil dehydrogenase), DPYD |
UniProt Protein Function: | DPYD: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. Homodimer. Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells. Belongs to the dihydropyrimidine dehydrogenase family. |
UniProt Protein Details: | Protein type:Other Amino Acids Metabolism - beta-alanine; EC 1.3.1.2; Xenobiotic Metabolism - drug metabolism - other enzymes; Oxidoreductase; Nucleotide Metabolism - pyrimidine; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis Chromosomal Location of Human Ortholog: 1p22 Cellular Component: cytoplasm; cytosol Molecular Function:protein homodimerization activity; FAD binding; dihydroorotate dehydrogenase activity; metal ion binding; 4 iron, 4 sulfur cluster binding; dihydropyrimidine dehydrogenase (NADP+) activity; NADP binding Biological Process: pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; uracil catabolic process; UMP biosynthetic process; thymine catabolic process; beta-alanine biosynthetic process; purine base catabolic process; pyrimidine base catabolic process; thymidine catabolic process Disease: Dihydropyrimidine Dehydrogenase Deficiency |
NCBI Summary: | The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
UniProt Code: | Q12882 |
NCBI GenInfo Identifier: | 160332325 |
NCBI Gene ID: | 1806 |
NCBI Accession: | Q12882.2 |
UniProt Secondary Accession: | Q12882,Q16694, Q16761, Q32NB0, Q96HL6, Q96TH1, A2RRQ2 A2RRQ3, A8K5A2, A8MWG9, B1AN21, E9PFN1, |
UniProt Related Accession: | Q12882 |
Molecular Weight: | 18,936 Da |
NCBI Full Name: | Dihydropyrimidine dehydrogenase |
NCBI Synonym Full Names: | dihydropyrimidine dehydrogenase |
NCBI Official Symbol: | DPYD |
NCBI Official Synonym Symbols: | DHP; DPD; DHPDHASE |
NCBI Protein Information: | dihydropyrimidine dehydrogenase [NADP(+)]; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrouracil dehydrogenase; dihydrothymine dehydrogenase |
UniProt Protein Name: | Dihydropyrimidine dehydrogenase [NADP(+)] |
UniProt Synonym Protein Names: | Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase |
UniProt Gene Name: | DPYD |
UniProt Entry Name: | DPYD_HUMAN |