DMRT1 Antibody, Biotin conjugated (PACO48809)
- SKU:
- PACO48809
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | DMRT1 Antibody, Biotin conjugated (PACO48809) |
抗体コード: | PACO48809 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Doublesex- and mab-3-related transcription factor 1 protein (195-363AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid, (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). |
シノニム: | Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1), DMRT1, DMT1 |
UniProt Protein Function: | DMRT1: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. Defects in DMRT1 may be a cause of testicular germ cell tumor (TGCT). A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms. Defects in DMRT1 may be a cause of 46,XY sex reversal type 4 (SRXY4). A condition characterized by male-to- female sex reversal in the presence of a normal 46,XY karyotype. Patients display complete or partial gonadal dysgenesis and a chromosome 9p deletion. Belongs to the DMRT family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 9p24.3 Cellular Component: nucleus Molecular Function:protein homodimerization activity; transcription factor activity Biological Process: male sex determination; male sex differentiation; negative regulation of meiosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitosis; positive regulation of transcription from RNA polymerase II promoter; Sertoli cell differentiation; sex differentiation |
NCBI Summary: | This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y5R6 |
NCBI GenInfo Identifier: | 83305820 |
NCBI Gene ID: | 1761 |
NCBI Accession: | Q9Y5R6.2 |
UniProt Secondary Accession: | Q9Y5R6,Q6T1H8, Q6T1H9, Q8IW77, B2R913, |
UniProt Related Accession: | Q9Y5R6 |
Molecular Weight: | 18,325 Da |
NCBI Full Name: | Doublesex- and mab-3-related transcription factor 1 |
NCBI Synonym Full Names: | doublesex and mab-3 related transcription factor 1 |
NCBI Official Symbol: | DMRT1 |
NCBI Official Synonym Symbols: | DMT1; CT154 |
NCBI Protein Information: | doublesex- and mab-3-related transcription factor 1 |
UniProt Protein Name: | Doublesex- and mab-3-related transcription factor 1 |
UniProt Synonym Protein Names: | DM domain expressed in testis protein 1 |
Protein Family: | Doublesex and mab-3 related transcription factor |
UniProt Gene Name: | DMRT1 |
UniProt Entry Name: | DMRT1_HUMAN |