DDC Antibody, Biotin conjugated (PACO49513)
- SKU:
- PACO49513
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | DDC Antibody, Biotin conjugated (PACO49513) |
抗体コード: | PACO49513 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Aromatic-L-amino-acid, decarboxylase protein (24-215AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. |
シノニム: | Aromatic-L-amino-acid, decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC), DDC, AADC |
UniProt Protein Function: | DDC: Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Homodimer. Belongs to the group II decarboxylase family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; EC 4.1.1.28; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; Nuclear receptor co-regulator; Amino Acid Metabolism - phenylalanine; Lyase Chromosomal Location of Human Ortholog: 7p12.2 Cellular Component: synaptic vesicle; cell soma; axon; cytosol Molecular Function:aromatic-L-amino-acid decarboxylase activity; protein domain specific binding; amino acid binding; protein binding; enzyme binding; pyridoxal phosphate binding Biological Process: circadian rhythm; amino acid metabolic process; catecholamine biosynthetic process; indolalkylamine biosynthetic process; multicellular organismal aging; isoquinoline alkaloid metabolic process; dopamine biosynthetic process; serotonin biosynthetic process; phytoalexin metabolic process; synaptic vesicle amine transport; response to pyrethroid Disease: Aromatic L-amino Acid Decarboxylase Deficiency |
NCBI Summary: | The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011] |
UniProt Code: | P20711 |
NCBI GenInfo Identifier: | 311033369 |
NCBI Gene ID: | 1644 |
NCBI Accession: | P20711.2 |
UniProt Secondary Accession: | P20711,O88533, P14173, |
UniProt Related Accession: | P20711 |
Molecular Weight: | 480 |
NCBI Full Name: | Aromatic-L-amino-acid decarboxylase |
NCBI Synonym Full Names: | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
NCBI Official Symbol: | DDC |
NCBI Official Synonym Symbols: | AADC |
NCBI Protein Information: | aromatic-L-amino-acid decarboxylase |
UniProt Protein Name: | Aromatic-L-amino-acid decarboxylase |
UniProt Synonym Protein Names: | DOPA decarboxylase; DDC |
Protein Family: | Aromatic-L-amino-acid decarboxylase |
UniProt Gene Name: | DDC |
UniProt Entry Name: | DDC_HUMAN |