CTPS1 Antibody (PACO26017)
- SKU:
- PACO26017
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CTPS1 Antibody (PACO26017) |
抗体コード: | PACO26017 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human CTP synthase 1 protein (300-554AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot All lanes: CTPS1 antibody at 6µg/ml Lane 1: Hela whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 67, 42 kDa Observed band size: 67 kDa . | |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO26017 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO26017 at dilution of 1:100. |
バックグラウンド: | This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. |
シノニム: | CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1), CTPS1, CTPS |
UniProt Protein Function: | CTPS: the enzyme cytidine-5-prime-triphosphate synthetase converts UTP to CTP. Important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 6.3.4.2; Nucleotide Metabolism - pyrimidine; Ligase Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: membrane; cytosol Molecular Function:CTP synthase activity; ATP binding Biological Process: T cell proliferation; B cell proliferation; response to drug; CTP biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; glutamine metabolic process Disease: Immunodeficiency 24 |
NCBI Summary: | This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
UniProt Code: | P17812 |
NCBI GenInfo Identifier: | 20981706 |
NCBI Gene ID: | 1503 |
NCBI Accession: | P17812.2 |
UniProt Related Accession: | P17812 |
Molecular Weight: | ~ 67kDa |
NCBI Full Name: | CTP synthase 1 |
NCBI Synonym Full Names: | CTP synthase 1 |
NCBI Official Symbol: | CTPS1 |
NCBI Official Synonym Symbols: | CTPS; GATD5; IMD24 |
NCBI Protein Information: | CTP synthase 1 |
UniProt Protein Name: | CTP synthase 1 |
UniProt Synonym Protein Names: | CTP synthetase 1; UTP--ammonia ligase 1 |
UniProt Gene Name: | CTPS1 |
UniProt Entry Name: | PYRG1_HUMAN |
Antibodies | ELISA Kits |
Anti-CTPS1 Antibody (CAB3817) | Human CTPS1 (CTP synthase 1) ELISA Kit (HUFI05332) |
CTPS1 Antibody (PACO06385) | |
CTPS1 Antibody (PACO08664) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |