CKAP5 Antibody, Biotin conjugated (PACO58127)
- SKU:
- PACO58127
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | CKAP5 Antibody, Biotin conjugated (PACO58127) |
抗体コード: | PACO58127 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Cytoskeleton-associated protein 5 protein (1802-2019AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments. |
シノニム: | Cytoskeleton-associated protein 5 (Colonic and hepatic tumor overexpressed gene protein) (Ch-TOG), CKAP5, KIAA0097 |
UniProt Protein Function: | CKAP5: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. Belongs to the TOG/XMAP215 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: microtubule cytoskeleton; spindle pole; centrosome; protein complex; membrane; cytosol; gamma-tubulin complex Molecular Function:protein binding Biological Process: mitosis; centrosome organization and biogenesis; cell division; organelle organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; spindle organization and biogenesis; RNA transport; establishment and/or maintenance of microtubule cytoskeleton polarity |
NCBI Summary: | This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q14008 |
NCBI GenInfo Identifier: | 57164942 |
NCBI Gene ID: | 9793 |
NCBI Accession: | NP_001008938.1 |
UniProt Secondary Accession: | Q14008,Q05D70, Q0VAX7, Q0VAX8, Q14668, Q2TA89, Q6NSH4 |
UniProt Related Accession: | Q14008 |
Molecular Weight: | 226,258 Da |
NCBI Full Name: | cytoskeleton-associated protein 5 isoform a |
NCBI Synonym Full Names: | cytoskeleton associated protein 5 |
NCBI Official Symbol: | CKAP5 |
NCBI Official Synonym Symbols: | TOG; MSPS; TOGp; CHTOG; ch-TOG |
NCBI Protein Information: | cytoskeleton-associated protein 5; colonic and hepatic tumor overexpressed gene protein; colonic and hepatic tumor over-expressed gene protein |
UniProt Protein Name: | Cytoskeleton-associated protein 5 |
UniProt Synonym Protein Names: | Colonic and hepatic tumor overexpressed gene protein; Ch-TOG |
Protein Family: | Cytoskeleton-associated protein |
UniProt Gene Name: | CKAP5 |
UniProt Entry Name: | CKAP5_HUMAN |