CIDEA Antibody, Biotin conjugated (PACO47357)
- SKU:
- PACO47357
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | CIDEA Antibody, Biotin conjugated (PACO47357) |
抗体コード: | PACO47357 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Cell death activator CIDE-A protein (1-51AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. |
シノニム: | Cell death activator CIDE-A (Cell death-inducing DFFA-like effector A), CIDEA |
UniProt Protein Function: | CIDEA: Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin- resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. |
UniProt Protein Details: | Protein type:Mitochondrial; Apoptosis Chromosomal Location of Human Ortholog: 18p11.21|18 Cellular Component: cytoplasm; lipid particle; mitochondrial envelope; mitochondrion; nucleus Molecular Function:protein homodimerization activity Biological Process: cell death; lipid metabolic process; negative regulation of cytokine secretion; negative regulation of lipid catabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tumor necrosis factor production; regulation of apoptosis; sequestering of lipid; thermoregulation |
NCBI Summary: | This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010] |
UniProt Code: | O60543 |
NCBI GenInfo Identifier: | 9087117 |
NCBI Gene ID: | 1149 |
NCBI Accession: | O60543.1 |
UniProt Secondary Accession: | O60543,Q6UPR7, B0YIY7, |
UniProt Related Accession: | O60543 |
Molecular Weight: | 24,687 Da |
NCBI Full Name: | Cell death activator CIDE-A |
NCBI Synonym Full Names: | cell death-inducing DFFA-like effector a |
NCBI Official Symbol: | CIDEA |
NCBI Official Synonym Symbols: | CIDE-A |
NCBI Protein Information: | cell death activator CIDE-A |
UniProt Protein Name: | Cell death activator CIDE-A |
UniProt Synonym Protein Names: | Cell death-inducing DFFA-like effector A |
Protein Family: | Cell death activator |
UniProt Gene Name: | CIDEA |
UniProt Entry Name: | CIDEA_HUMAN |