CHAC1 Antibody, Biotin conjugated (PACO41837)
- SKU:
- PACO41837
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | CHAC1 Antibody, Biotin conjugated (PACO41837) |
抗体コード: | PACO41837 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Glutathione-specific gamma-glutamylcyclotransferase 1 protein (43-264AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. |
シノニム: | Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 4.3.2.-) (Blocks Notch protein) (Botch) (Cation transport regulator-like protein 1), CHAC1, BOTCH |
UniProt Protein Function: | CHAC1: Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Belongs to the chaC family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 15q15.1 Cellular Component: trans-Golgi network; cytosol Molecular Function:protein binding; transferase activity, transferring acyl groups; Notch binding Biological Process: Notch signaling pathway; neurogenesis; metabolic process; negative regulation of Notch signaling pathway; response to unfolded protein |
UniProt Code: | Q9BUX1 |
NCBI GenInfo Identifier: | 218563698 |
NCBI Gene ID: | 79094 |
NCBI Accession: | NP_077016.2 |
UniProt Secondary Accession: | Q9BUX1,Q0VIA0, |
UniProt Related Accession: | Q9BUX1 |
Molecular Weight: | 23,795 Da |
NCBI Full Name: | cation transport regulator-like protein 1 isoform a |
NCBI Synonym Full Names: | ChaC, cation transport regulator homolog 1 (E. coli) |
NCBI Official Symbol: | CHAC1 |
NCBI Protein Information: | cation transport regulator-like protein 1; botch; blocks Notch protein; ChaC, cation transport regulator-like 1; gamma-GCT acting on glutathione homolog 1 |
UniProt Protein Name: | Cation transport regulator-like protein 1 |
UniProt Synonym Protein Names: | Blocks Notch protein; Botch |
Protein Family: | Glutathione-specific gamma-glutamylcyclotransferase |
UniProt Gene Name: | CHAC1 |
UniProt Entry Name: | CHAC1_HUMAN |