Cd74 Antibody, HRP conjugated (PACO25627)
- SKU:
- PACO25627
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | Cd74 Antibody, HRP conjugated (PACO25627) |
抗体コード: | PACO25627 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Rat |
免疫原: | Recombinant Rat H-2 class II histocompatibility antigen γ chain protein (57-280AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/β heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. |
シノニム: | H-2 class II histocompatibility antigen γ chain (Ia antigen-associated invariant chain) (Ii) (MHC class II-associated invariant chain) (CD antigen CD74), Cd74 |
UniProt Protein Function: | CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Endoplasmic reticulum; Membrane protein, integral; Receptor, cytokineCellular Component: cell surface; endoplasmic reticulum; external side of plasma membrane; Golgi apparatus; integral to membrane; late endosome; lysosome; membrane; MHC class II protein complex; multivesicular body; plasma membrane; vacuoleMolecular Function: beta-amyloid binding; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; MHC class II protein binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase bindingBiological Process: activation of MAPK activity; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; chaperone cofactor-dependent protein folding; defense response; immunoglobulin mediated immune response; intracellular protein transport; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of peptide secretion; negative regulation of T cell differentiation; negative thymic T cell selection; positive regulation of B cell proliferation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of dendritic cell antigen processing and presentation; positive regulation of fibroblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; positive regulation of T-helper 2 type immune response; positive thymic T cell selection; prostaglandin biosynthetic process; protein complex assembly; signal transduction |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | P10247 |
NCBI GenInfo Identifier: | 6978637 |
NCBI Gene ID: | 25599 |
NCBI Accession: | NP_037201.1 |
UniProt Secondary Accession: | P10247 |
UniProt Related Accession: | P10247 |
Molecular Weight: | 29.5 kDa |
NCBI Full Name: | H-2 class II histocompatibility antigen gamma chain |
NCBI Synonym Full Names: | CD74 molecule |
NCBI Official Symbol: | Cd74 |
NCBI Official Synonym Symbols: | INVG34 |
NCBI Protein Information: | H-2 class II histocompatibility antigen gamma chain |
UniProt Protein Name: | H-2 class II histocompatibility antigen gamma chain |
UniProt Synonym Protein Names: | Ia antigen-associated invariant chain; Ii; MHC class II-associated invariant chain; CD_antigen: CD74 |
Protein Family: | H-2 class II histocompatibility antigen |
UniProt Gene Name: | Cd74 |
UniProt Entry Name: | HG2A_RAT |