| UniProt Protein Function: | CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Endoplasmic reticulum; Receptor, cytokineCellular Component: cell surface; endoplasmic reticulum; external side of plasma membrane; Golgi apparatus; integral to membrane; integral to plasma membrane; late endosome; lysosome; membrane; MHC class II protein complex; multivesicular body; plasma membrane; vacuoleMolecular Function: beta-amyloid binding; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; MHC class II protein binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding; protein bindingBiological Process: activation of MAPK activity; adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; chaperone cofactor-dependent protein folding; defense response; immune response; immune system process; immunoglobulin mediated immune response; intracellular protein transport; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of peptide secretion; negative regulation of T cell differentiation; negative thymic T cell selection; positive regulation of adaptive immune response; positive regulation of B cell proliferation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of dendritic cell antigen processing and presentation; positive regulation of fibroblast proliferation; positive regulation of innate immune response; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; positive regulation of T-helper 2 type immune response; positive thymic T cell selection; prostaglandin biosynthetic process; protein complex assembly; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P04441 |
| NCBI GenInfo Identifier: | 110624770 |
| NCBI Gene ID: | 16149 |
| NCBI Accession: | NP_001036070.1 |
| UniProt Secondary Accession: | P04441,O19452 |
| UniProt Related Accession: | P04441 |
| Molecular Weight: | 29.4 kDa |
| NCBI Full Name: | H-2 class II histocompatibility antigen gamma chain isoform 1 |
| NCBI Synonym Full Names: | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) |
| NCBI Official Symbol: | Cd74 |
| NCBI Official Synonym Symbols: | Ii; CLIP; DHLAG; HLADG; Ia-GAMMA |
| NCBI Protein Information: | H-2 class II histocompatibility antigen gamma chain |
| UniProt Protein Name: | H-2 class II histocompatibility antigen gamma chain |
| UniProt Synonym Protein Names: | Ia antigen-associated invariant chain; Ii; MHC class II-associated invariant chain; CD_antigen: CD74 |
| Protein Family: | H-2 class II histocompatibility antigen |
| UniProt Gene Name: | Cd74 |
| UniProt Entry Name: | HG2A_MOUSE |
