BRAP Antibody, Biotin conjugated (PACO58247)
- SKU:
- PACO58247
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | BRAP Antibody, Biotin conjugated (PACO58247) |
抗体コード: | PACO58247 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human BRCA1-associated protein (13-124AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. |
シノニム: | BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63), BRAP, RNF52 |
UniProt Protein Function: | BRAP: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 12q24 Cellular Component: cytoplasm; cytosol; nuclear membrane; ubiquitin ligase complex Molecular Function:identical protein binding; nuclear localization sequence binding; protein binding; ubiquitin binding; ubiquitin-protein ligase activity Biological Process: MAPKKK cascade; negative regulation of signal transduction; protein ubiquitination; Ras protein signal transduction |
NCBI Summary: | The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q7Z569 |
NCBI GenInfo Identifier: | 296434410 |
NCBI Gene ID: | 8315 |
NCBI Accession: | Q7Z569.2 |
UniProt Secondary Accession: | Q7Z569,O43238, O75341, B4DRM1, B9EGS8, |
UniProt Related Accession: | Q7Z569 |
Molecular Weight: | 47,853 Da |
NCBI Full Name: | BRCA1-associated protein |
NCBI Synonym Full Names: | BRCA1 associated protein |
NCBI Official Symbol: | BRAP |
NCBI Official Synonym Symbols: | IMP; BRAP2; RNF52 |
NCBI Protein Information: | BRCA1-associated protein |
UniProt Protein Name: | BRCA1-associated protein |
UniProt Synonym Protein Names: | BRAP2; Impedes mitogenic signal propagation; IMP; RING finger protein 52; Renal carcinoma antigen NY-REN-63 |
UniProt Gene Name: | BRAP |
UniProt Entry Name: | BRAP_HUMAN |