BHLHE41 Antibody, Biotin conjugated (PACO57543)
- SKU:
- PACO57543
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | BHLHE41 Antibody, Biotin conjugated (PACO57543) |
抗体コード: | PACO57543 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Class E basic helix-loop-helix protein 41 protein (185-285AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. |
シノニム: | Class E basic helix-loop-helix protein 41 (bHLHe41) (Class B basic helix-loop-helix protein 3) (bHLHb3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1), BHLHE41, BHLHB3 DEC2 SHARP1 |
UniProt Protein Function: | BHLHB3: May be a transcriptional repressor that represses both basal and activated transcription. Homodimerize. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 12p12.1 Molecular Function:bHLH transcription factor binding; histone deacetylase binding; MRF binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription corepressor activity Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent Disease: Short Sleeper |
NCBI Summary: | This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014] |
UniProt Code: | Q9C0J9 |
NCBI GenInfo Identifier: | 20137459 |
NCBI Gene ID: | 79365 |
NCBI Accession: | Q9C0J9.1 |
UniProt Secondary Accession: | Q9C0J9,A2I2N8, |
UniProt Related Accession: | Q9C0J9 |
Molecular Weight: | 50kDa |
NCBI Full Name: | Class E basic helix-loop-helix protein 41 |
NCBI Synonym Full Names: | basic helix-loop-helix family member e41 |
NCBI Official Symbol: | BHLHE41 |
NCBI Official Synonym Symbols: | DEC2; hDEC2; BHLHB3; SHARP1 |
NCBI Protein Information: | class E basic helix-loop-helix protein 41 |
UniProt Protein Name: | Class E basic helix-loop-helix protein 41 |
UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 3; bHLHb3; Differentially expressed in chondrocytes protein 2; hDEC2; Enhancer-of-split and hairy-related protein 1; SHARP-1 |
Protein Family: | Class E basic helix-loop-helix protein |
UniProt Gene Name: | BHLHE41 |