BBC3 Antibody, FITC conjugated (PACO63201)
- SKU:
- PACO63201
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | BBC3 Antibody, FITC conjugated (PACO63201) |
抗体コード: | PACO63201 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Peptide sequence from Human Bcl-2-binding component 3 protein (5-23AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. |
シノニム: | Bcl-2-binding component 3 (JFY-1) (p53 up-regulated modulator of apoptosis), BBC3, PUMA |
UniProt Protein Function: | PUMA: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Interacts with MCL1 and BCL2A1. Interacts with BCL2 and BCL2L1/BCL-XL. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. Ubiquitously expressed. Belongs to the Bcl-2 family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 19q13.3-q13.4 Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol Molecular Function:protein binding Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of protein homooligomerization; apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of neuron apoptosis; release of sequestered calcium ion into cytosol; determination of adult life span; response to DNA damage stimulus; negative regulation of growth |
NCBI Summary: | This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q9BXH1 |
NCBI GenInfo Identifier: | 56748610 |
NCBI Gene ID: | 27113 |
NCBI Accession: | Q9BXH1.1 |
UniProt Secondary Accession: | Q9BXH1,O00171, Q96PG9, B9EGI3, |
UniProt Related Accession: | Q96PG8,Q9BXH1 |
Molecular Weight: | 193 |
NCBI Full Name: | Bcl-2-binding component 3 |
NCBI Synonym Full Names: | BCL2 binding component 3 |
NCBI Official Symbol: | BBC3 |
NCBI Official Synonym Symbols: | JFY1; PUMA; JFY-1 |
NCBI Protein Information: | bcl-2-binding component 3; p53 up-regulated modulator of apoptosis |
UniProt Protein Name: | Bcl-2-binding component 3 |
UniProt Synonym Protein Names: | JFY-1; p53 up-regulated modulator of apoptosis |
Protein Family: | Bcl-2-binding component |
UniProt Gene Name: | BBC3 |
UniProt Entry Name: | BBC3_HUMAN |