AZIN1 Antibody, Biotin conjugated (PACO25179)
- SKU:
- PACO25179
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | AZIN1 Antibody, Biotin conjugated (PACO25179) |
抗体コード: | PACO25179 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Antizyme inhibitor 1 protein (101-400AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. |
シノニム: | Antizyme inhibitor 1 (AZI) (AZI1) (Ornithine decarboxylase antizyme inhibitor), AZIN1, OAZI OAZIN |
UniProt Protein Function: | AZIN1: Regulates cellular polyamine homeostasis. Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme. Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 8q22.3 Cellular Component: nucleus; cytosol Molecular Function:enzyme inhibitor activity; ornithine decarboxylase activator activity; catalytic activity Biological Process: positive regulation of catalytic activity; polyamine biosynthetic process; negative regulation of catalytic activity; regulation of amino acid metabolic process; negative regulation of protein catabolic process |
NCBI Summary: | The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014] |
UniProt Code: | O14977 |
NCBI GenInfo Identifier: | 33860187 |
NCBI Gene ID: | 51582 |
NCBI Accession: | O14977.2 |
UniProt Secondary Accession: | O14977,Q6IBQ7, Q96D20, A6NCD5, |
UniProt Related Accession: | O14977 |
Molecular Weight: | 49,535 Da |
NCBI Full Name: | Antizyme inhibitor 1 |
NCBI Synonym Full Names: | antizyme inhibitor 1 |
NCBI Official Symbol: | AZIN1 |
NCBI Official Synonym Symbols: | AZI; OAZI; AZIA1; OAZIN; ODC1L |
NCBI Protein Information: | antizyme inhibitor 1; ornithine decarboxylase antizyme inhibitor |
UniProt Protein Name: | Antizyme inhibitor 1 |
UniProt Synonym Protein Names: | Ornithine decarboxylase antizyme inhibitor |
Protein Family: | Antizyme inhibitor |
UniProt Gene Name: | AZIN1 |
UniProt Entry Name: | AZIN1_HUMAN |