ATP6V0A1 Antibody, FITC conjugated (PACO53524)
- SKU:
- PACO53524
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | ATP6V0A1 Antibody, FITC conjugated (PACO53524) |
抗体コード: | PACO53524 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human V-type proton ATPase 116 kDa subunit a isoform 1 protein (80-260AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). |
シノニム: | V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1), ATP6V0A1, ATP6N1 ATP6N1A VPP1 |
UniProt Protein Function: | ATP6V0A1: Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle. Belongs to the V-ATPase 116 kDa subunit family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Transporter, iron Chromosomal Location of Human Ortholog: 17q21 Cellular Component: nucleoplasm; Golgi apparatus; phagocytic vesicle membrane; intracellular membrane-bound organelle; cytoplasm; melanosome; integral to membrane; plasma membrane; endosome membrane; vacuolar proton-transporting V-type ATPase complex Molecular Function:protein binding; hydrogen ion transporting ATPase activity, rotational mechanism; ATPase binding Biological Process: interaction with host; vacuolar acidification; ATP synthesis coupled proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport |
NCBI Summary: | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q93050 |
NCBI GenInfo Identifier: | 59803038 |
NCBI Gene ID: | 535 |
NCBI Accession: | Q93050.3 |
UniProt Secondary Accession: | Q93050,Q8N5G7, Q9NSX0, B7Z3B7, |
UniProt Related Accession: | Q93050 |
Molecular Weight: | 96,600 Da |
NCBI Full Name: | V-type proton ATPase 116 kDa subunit a isoform 1 |
NCBI Synonym Full Names: | ATPase, H+ transporting, lysosomal V0 subunit a1 |
NCBI Official Symbol: | ATP6V0A1 |
NCBI Official Synonym Symbols: | a1; Stv1; VPP1; Vph1; ATP6N1; ATP6N1A |
NCBI Protein Information: | V-type proton ATPase 116 kDa subunit a isoform 1; V-ATPase 116 kDa; vacuolar proton pump subunit 1; vacuolar proton pump, subunit 1; vacuolar-type H(+)-ATPase 115 kDa subunit; vacuolar adenosine triphosphatase subunit Ac116; vacuolar proton translocating ATPase 116 kDa subunit A; H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD) |
UniProt Protein Name: | V-type proton ATPase 116 kDa subunit a isoform 1 |
UniProt Synonym Protein Names: | Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 |
Protein Family: | V-type proton ATPase |
UniProt Gene Name: | ATP6V0A1 |
UniProt Entry Name: | VPP1_HUMAN |