APH1B Antibody, FITC conjugated (PACO63825)
- SKU:
- PACO63825
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | APH1B Antibody, FITC conjugated (PACO63825) |
抗体コード: | PACO63825 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Peptide sequence from Human Gamma-secretase subunit APH-1B protein (93-110AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. |
シノニム: | Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like), APH1B, PSFL |
UniProt Protein Function: | APH1B: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. Belongs to the APH-1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q22.2 Cellular Component: integral to membrane; plasma membrane; transport vesicle Molecular Function:peptidase activity; protein binding Biological Process: ephrin receptor signaling pathway; membrane protein intracellular domain proteolysis; Notch receptor processing; Notch signaling pathway; positive regulation of apoptosis; positive regulation of catalytic activity; protein processing |
NCBI Summary: | This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q8WW43 |
NCBI GenInfo Identifier: | 61252592 |
NCBI Gene ID: | 83464 |
NCBI Accession: | Q8WW43.3 |
UniProt Secondary Accession: | Q8WW43,Q564N3, Q6UWQ1, Q9H0S0, A8K589, |
UniProt Related Accession: | Q8WW43 |
Molecular Weight: | 24,282 Da |
NCBI Full Name: | Gamma-secretase subunit APH-1B |
NCBI Synonym Full Names: | aph-1 homolog B, gamma-secretase subunit |
NCBI Official Symbol: | APH1B |
NCBI Official Synonym Symbols: | PSFL; APH-1B; PRO1328; TAAV688 |
NCBI Protein Information: | gamma-secretase subunit APH-1B |
UniProt Protein Name: | Gamma-secretase subunit APH-1B |
UniProt Synonym Protein Names: | Aph-1beta; Presenilin-stabilization factor-like |
Protein Family: | Gamma-secretase |
UniProt Gene Name: | APH1B |
UniProt Entry Name: | APH1B_HUMAN |