Anti-ZP2 Antibody (CAB10126)
- SKU:
- CAB10126
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-ZP2 Antibody |
抗体コード: | CAB10126 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 651-745 of human ZP2 (NP_003451.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:1000 - 1:4000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SH-SY5Y, HL-60, SW620, Mouse liver, Rat ovary |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 651-745 of human ZP2 (NP_003451.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KMTV SLPG PILL LSDD SSFR GVGS SDLK ASGS SGEK SRSE TGEE VGSR GAMD TKGH KTAG DVGS KAVA AVAA FAGV VATL GFIY YLYE KRTV SNH |
遺伝子ID: | 7783 |
Uniprot: | Q05996 |
セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein, extracellular matrix, extracellular space |
計算された分子量: | 81kDa/82kDa |
観察された分子量: | 68kDa |
同義語: | ZP2, ZPA, Zp-2 |
バックグラウンド: | The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | ZP2: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 16p12 Cellular Component: endoplasmic reticulum; extracellular matrix; extracellular region; Golgi apparatus; integral to membrane; multivesicular body; plasma membrane; proteinaceous extracellular matrix; secretory granule Molecular Function:acrosin binding; coreceptor activity Biological Process: binding of sperm to zona pellucida; intracellular protein transport; manganese ion transport; regulation of acrosome reaction; signal transduction |
NCBI Summary: | The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
UniProt Code: | Q05996 |
NCBI GenInfo Identifier: | 4508045 |
NCBI Gene ID: | 7783 |
NCBI Accession: | NP_003451.1 |
UniProt Related Accession: | Q05996 |
Molecular Weight: | |
NCBI Full Name: | zona pellucida sperm-binding protein 2 isoform 1 preproprotein |
NCBI Synonym Full Names: | zona pellucida glycoprotein 2 |
NCBI Official Symbol: | ZP2 |
NCBI Official Synonym Symbols: | ZPA; Zp-2; OOMD6 |
NCBI Protein Information: | zona pellucida sperm-binding protein 2 |
UniProt Protein Name: | Zona pellucida sperm-binding protein 2 |
UniProt Synonym Protein Names: | Zona pellucida glycoprotein 2; Zp-2 |
Protein Family: | Zona pellucida sperm-binding protein |
UniProt Gene Name: | ZP2 |
UniProt Entry Name: | ZP2_HUMAN |
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