Anti-YARS2 Antibody (CAB7976)
- SKU:
- CAB7976
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | YARS2 Rabbit Polyclonal Antibody |
抗体コード: | CAB7976 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 228-477 of human YARS2 (NP_001035526.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HepG2, SKOV3, HT-29, Mouse brain, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 228-477 of human YARS2 (NP_001035526.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | DFYY LFQR YGCR VQLG GSDQ LGNI MSGY EFIN KLTG EDVF GITV PLIT STTG AKLG KSAG NAVW LNRD KTSP FELY QFFV RQPD DSVE RYLK LFTF LPLP EIDH IMQL HVKE PERR GPQK RLAA EVTK LVHG REGL DSAK RCTQ ALYH SSID ALEV MSDQ ELKE LFKE APFS EFFL DPGT SVLD TCRK ANAI PDGP RGYR MITE GGVS INHQ QVTN PESV LIVG QHIL KNGL SLLK IGKR NFYI IKWL QL |
遺伝子ID: | 51067 |
Uniprot: | Q9Y2Z4 |
セルラーロケーション: | Mitochondrion matrix |
計算された分子量: | 53kDa |
観察された分子量: | 53kDa |
同義語: | YARS2, CGI-04, MLASA2, MT-TYRRS, TYRRS |
バックグラウンド: | This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). |
UniProt Protein Function: | YARS2: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia. Belongs to the class-I aminoacyl-tRNA synthetase family. |
UniProt Protein Details: | Protein type:RNA-binding; Ligase; Translation; Mitochondrial; EC 6.1.1.1 Chromosomal Location of Human Ortholog: 12p11.21 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:protein homodimerization activity; tyrosine-tRNA ligase activity; ATP binding; tRNA binding Biological Process: tRNA aminoacylation for protein translation; translation; gene expression; tRNA aminoacylation Disease: Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2 |
NCBI Summary: | This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011] |
UniProt Code: | Q9Y2Z4 |
NCBI GenInfo Identifier: | 50401709 |
NCBI Gene ID: | 51067 |
NCBI Accession: | Q9Y2Z4.2 |
UniProt Secondary Accession: | Q9Y2Z4,Q9H817, D3DUW8, |
UniProt Related Accession: | Q9Y2Z4 |
Molecular Weight: | 477 |
NCBI Full Name: | Tyrosine--tRNA ligase, mitochondrial |
NCBI Synonym Full Names: | tyrosyl-tRNA synthetase 2, mitochondrial |
NCBI Official Symbol: | YARS2 |
NCBI Official Synonym Symbols: | TYRRS; CGI-04; MLASA2; MT-TYRRS |
NCBI Protein Information: | tyrosine--tRNA ligase, mitochondrial; tyrosine tRNA ligase 2, mitochondrial |
UniProt Protein Name: | Tyrosine--tRNA ligase, mitochondrial |
UniProt Synonym Protein Names: | Tyrosyl-tRNA synthetase; TyrRS |
UniProt Gene Name: | YARS2 |
UniProt Entry Name: | SYYM_HUMAN |
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