Anti-VPS16 Antibody (CAB15888)
- SKU:
- CAB15888
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
抗体名: | Anti-VPS16 Antibody |
抗体コード: | CAB15888 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-839 of human VPS16 (NP_072097.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, Mouse brain, Mouse lung, Rat pancreas |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-839 of human VPS16 (NP_072097.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | EYEP RSGE QVPL LLKM KRSK LALS KAIE SGDT DLVF TVLL HLKN ELNR GDFF MTLR NQPM ALSL YRQF CKHQ ELET LKDL YNQD DNHQ ELGS FHIR ASYA AEER IEGR VAAL QTAA DAFY KAKN EFAA KATE DQMR LLRL QRRL EDEL GGQF LDLS LHDT VTTL ILGG HNKR AEQL ARDF RIPD KRLW WLKL TALA DLED WEEL EKFS KSKK SPIG YLPF VEIC MKQH NKYE AKKY ASRV GPEQ KVKA LLLV GDVA QAAD VAIE HRNE AELS LVLS HCTG ATDG ATAD KIQR ARAQ AQKK |
遺伝子ID: | 64601 |
Uniprot: | Q9H269 |
セルラーロケーション: | Cytoplasmic side, Cytoplasmic vesicle, Early endosome, Late endosome membrane, Lysosome membrane, Peripheral membrane protein, autophagosome, clathrin-coated vesicle |
計算された分子量: | 78kDa/94kDa |
観察された分子量: | 95kDa |
同義語: | VPS16, hVPS16 |
バックグラウンド: | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770). |
NCBI Summary: | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009] |
UniProt Code: | Q9H269 |
NCBI GenInfo Identifier: | 17978479 |
NCBI Gene ID: | 64601 |
NCBI Accession: | NP_072097.2 |
UniProt Secondary Accession: | Q9H269,Q5JUB1, Q8WU31, Q96EE7, Q96N92, Q9H1Q4, Q9H1Q5 |
UniProt Related Accession: | Q9H269 |
Molecular Weight: | 78,300 Da |
NCBI Full Name: | vacuolar protein sorting-associated protein 16 homolog isoform 1 |
NCBI Synonym Full Names: | VPS16, CORVET/HOPS core subunit |
NCBI Official Symbol: | VPS16 |
NCBI Official Synonym Symbols: | hVPS16 |
NCBI Protein Information: | vacuolar protein sorting-associated protein 16 homolog |
UniProt Protein Name: | Vacuolar protein sorting-associated protein 16 homolog |
Protein Family: | Vacuolar protein sorting-associated protein |
UniProt Gene Name: | VPS16 |
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