Anti-UBE2N Antibody (CAB10543)
- SKU:
- CAB10543
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-UBE2N Antibody |
抗体コード: | CAB10543 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human UBE2N (NP_003339.1). |
申し込み: | WB |
推奨希釈: | WB 1:1000 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-251MG, B cells, Mouse brain, Mouse spleen, Rat brain, Rat testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human UBE2N (NP_003339.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAGL PRRI IKET QRLL AEPV PGIK AEPD ESNA RYFH VVIA GPQD SPFE GGTF KLEL FLPE EYPM AAPK VRFM TKIY HPNV DKLG RICL DILK DKWS PALQ IRTV LLSI QALL SAPN PDDP LAND VAEQ WKTN EAQA IETA RAWT RLYA MNNI |
遺伝子ID: | 7334 |
Uniprot: | P61088 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 17kDa |
観察された分子量: | 17kDa |
同義語: | UBE2N, HEL-S-71, UBC13, UBCHBEN, UbcH-ben, UbcH13 |
バックグラウンド: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. |
UniProt Protein Function: | The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. |
NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008] |
UniProt Code: | P61088 |
NCBI GenInfo Identifier: | 46577660 |
NCBI Gene ID: | 7334 |
NCBI Accession: | P61088.1 |
UniProt Secondary Accession: | P61088,Q16781, Q53Y81, |
UniProt Related Accession: | P61088 |
Molecular Weight: | 17kDa |
NCBI Full Name: | Ubiquitin-conjugating enzyme E2 N |
NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 N |
NCBI Official Symbol: | UBE2N |
NCBI Official Synonym Symbols: | UBC13; UbcH13; HEL-S-71; UbcH-ben; UBCHBEN; UBC13 |
NCBI Protein Information: | ubiquitin-conjugating enzyme E2 N |
UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 N |
UniProt Synonym Protein Names: | Bendless-like ubiquitin-conjugating enzyme; E2 ubiquitin-conjugating enzyme N; Ubc13; UbcH13; Ubiquitin carrier protein N; Ubiquitin-protein ligase N |
Protein Family: | Ubiquitin-conjugating enzyme |
UniProt Gene Name: | UBE2N |
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