Anti-UBE2M Antibody (CAB9007)
- SKU:
- CAB9007
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-UBE2M Antibody |
抗体コード: | CAB9007 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human UBE2M (NP_003960.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, 293T, Mouse kidney, Mouse heart, Mouse testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human UBE2M (NP_003960.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MIKL FSLK QQKK EEES AGGT KGSS KKAS AAQL RIQK DINE LNLP KTCD ISFS DPDD LLNF KLVI CPDE GFYK SGKF VFSF KVGQ GYPH DPPK VKCE TMVY HPNI DLEG NVCL NILR EDWK PVLT INSI IYGL QYLF LEPN PEDP LNKE AAEV LQNN RRLF EQNV QRSM RGGY IGST YFER CLK |
遺伝子ID: | 9040 |
Uniprot: | P61081 |
セルラーロケーション: | |
計算された分子量: | 20kDa |
観察された分子量: | 21kDa |
同義語: | UBE2M, UBC-RS2, UBC12, hUbc12 |
バックグラウンド: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. |
UniProt Protein Function: | Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. |
NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008] |
UniProt Code: | P61081 |
NCBI GenInfo Identifier: | 4507791 |
NCBI Gene ID: | 9040 |
NCBI Accession: | NP_003960.1 |
UniProt Secondary Accession: | P61081,O76069, Q8VC50, |
UniProt Related Accession: | P61081 |
Molecular Weight: | Observed: 21 kDaPredicted: 21 kDa |
NCBI Full Name: | NEDD8-conjugating enzyme Ubc12 |
NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 M |
NCBI Official Symbol: | UBE2M |
NCBI Official Synonym Symbols: | UBC12; hUbc12; UBC-RS2 |
NCBI Protein Information: | NEDD8-conjugating enzyme Ubc12 |
UniProt Protein Name: | NEDD8-conjugating enzyme Ubc12 |
UniProt Synonym Protein Names: | NEDD8 carrier protein; Ubiquitin-conjugating enzyme E2 M |
UniProt Gene Name: | UBE2M |
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