Anti-TYROBP Antibody (CAB5385)
- SKU:
- CAB5385
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-TYROBP Antibody |
抗体コード: | CAB5385 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | IHC |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human TYROBP (NP_003323.1). |
申し込み: | IHC |
推奨希釈: | IHC 1:50 - 1:200 |
反応性: | Mouse, Rat |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human TYROBP (NP_003323.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MGGL EPCS RLLL LPLL LAVS GLRP VQAQ AQSD CSCS TVSP GVLA GIVM GDLV LTVL IALA VYFL GRLV PRGR GAAE AATR KQRI TETE SPYQ ELQG QRSD VYSD LNTQ RPYY K |
遺伝子ID: | 7305 |
Uniprot: | O43914 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 11kDa/12kDa |
観察された分子量: |
同義語: | TYROBP, DAP12, KARAP, PLOSL |
バックグラウンド: | This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. |
UniProt Protein Function: | TYROBP: Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. Defects in TYROBP are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. Belongs to the TYROBP family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function:identical protein binding; protein binding; receptor signaling protein activity; receptor binding Biological Process: integrin-mediated signaling pathway; axon guidance; regulation of immune response; neutrophil activation during immune response; macrophage activation during immune response; innate immune response; cellular defense response; signal transduction Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy |
NCBI Summary: | This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010] |
UniProt Code: | O43914 |
NCBI GenInfo Identifier: | 7531221 |
NCBI Gene ID: | 7305 |
NCBI Accession: | O43914.1 |
UniProt Secondary Accession: | O43914,Q6FGA5, Q9UMT3, A8K2X0, F5H389, |
UniProt Related Accession: | O43914 |
Molecular Weight: | 113 |
NCBI Full Name: | TYRO protein tyrosine kinase-binding protein |
NCBI Synonym Full Names: | TYRO protein tyrosine kinase binding protein |
NCBI Official Symbol: | TYROBP |
NCBI Official Synonym Symbols: | DAP12; KARAP; PLOSL |
NCBI Protein Information: | TYRO protein tyrosine kinase-binding protein; KAR-associated protein; DNAX-activation protein 12; killer-activating receptor-associated protein |
UniProt Protein Name: | TYRO protein tyrosine kinase-binding protein |
UniProt Synonym Protein Names: | DNAX-activation protein 12; Killer-activating receptor-associated protein; KAR-associated protein |
Protein Family: | TYRO protein tyrosine kinase-binding protein |
UniProt Gene Name: | TYROBP |
UniProt Entry Name: | TYOBP_HUMAN |
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