Anti-TOLLIP Antibody (CAB2202)
- SKU:
- CAB2202
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Autophagy
Frequently bought together:
Description
抗体名: | Anti-TOLLIP Antibody |
抗体コード: | CAB2202 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human TOLLIP (NP_061882.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SW480, OVCAR3, MCF7, 293T, Mouse spleen, Mouse intestine, Mouse liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human TOLLIP (NP_061882.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MATT VSTQ RGPV YIGE LPQD FLRI TPTQ QQRQ VQLD AQAA QQLQ YGGA VGTV GRLN ITVV QAKL AKNY GMTR MDPY CRLR LGYA VYET PTAH NGAK NPRW NKVI HCTV PPGV DSFY LEIF DERA FSMD DRIA WTHI TIPE SLRQ GKVE DKWY SLSG RQGD DKEG MINL VMSY ALLP AAMV MPPQ PVVL MPTV YQQG VGYV PITG MPAV CSPG MVPV ALPP AAVN AQPR CSEE DLKA IQDM FPNM DQEV IRSV LEAQ RGNK DAAI NSLL QMGE EP |
遺伝子ID: | 54472 |
Uniprot: | Q9H0E2 |
セルラーロケーション: | Cytoplasm |
計算された分子量: | 22kDa/30kDa |
観察された分子量: | 30kDa |
同義語: | TOLLIP, IL-1RAcPIP |
バックグラウンド: | This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | TOLLIP: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2. Belongs to the tollip family. |
UniProt Protein Details: | Protein type:Vesicle; Inhibitor Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: cytoplasm; cytosol Molecular Function:kinase binding; protein binding Biological Process: cell-cell signaling; epithelial cell differentiation; phosphorylation; signal transduction |
NCBI Summary: | This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
UniProt Code: | Q9H0E2 |
NCBI GenInfo Identifier: | 20140803 |
NCBI Gene ID: | 54472 |
NCBI Accession: | Q9H0E2.1 |
UniProt Secondary Accession: | Q9H0E2,Q9H9E6, Q9UJ69, B3KXC6, |
UniProt Related Accession: | Q9H0E2 |
Molecular Weight: | 22,812 Da |
NCBI Full Name: | Toll-interacting protein |
NCBI Synonym Full Names: | toll interacting protein |
NCBI Official Symbol: | TOLLIP |
NCBI Official Synonym Symbols: | IL-1RAcPIP |
NCBI Protein Information: | toll-interacting protein |
UniProt Protein Name: | Toll-interacting protein |
Protein Family: | Toll-interacting protein |
UniProt Gene Name: | TOLLIP |
UniProt Entry Name: | TOLIP_HUMAN |
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