Anti-TNFSF10 Antibody (CAB11984)
- SKU:
- CAB11984
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
抗体名: | Anti-TNFSF10 Antibody |
抗体コード: | CAB11984 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TNFSF10 (NP_003801.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Rat |
ポジティブサンプル: | Rat lung |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TNFSF10 (NP_003801.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAMM EVQG GPSL GQTC VLIV IFTV LLQS LCVA VTYV YFTN ELKQ MQDK YSKS GIAC FLKE DDSY WDPN DEES MNSP CWQV KWQL RQLV RKMI LRTS EETI |
遺伝子ID: | 8743 |
Uniprot: | P50591 |
セルラーロケーション: | Membrane, Single-pass type II membrane protein |
計算された分子量: | 11kDa/32kDa |
観察された分子量: | 20kDa |
同義語: | TNFSF10, APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL |
バックグラウンド: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. |
NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
UniProt Code: | P50591 |
NCBI GenInfo Identifier: | 1730015 |
NCBI Gene ID: | 8743 |
NCBI Accession: | P50591.1 |
UniProt Secondary Accession: | P50591,A1Y9B3, |
UniProt Related Accession: | P50591 |
Molecular Weight: | 11,746 Da |
NCBI Full Name: | Tumor necrosis factor ligand superfamily member 10 |
NCBI Synonym Full Names: | TNF superfamily member 10 |
NCBI Official Symbol: | TNFSF10 |
NCBI Official Synonym Symbols: | TL2; APO2L; CD253; TRAIL; Apo-2L; TNLG6A |
NCBI Protein Information: | tumor necrosis factor ligand superfamily member 10 |
UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 10 |
UniProt Synonym Protein Names: | Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253 |
UniProt Gene Name: | TNFSF10 |
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