Anti-TNFRSF10C Antibody (CAB1137)
- SKU:
- CAB1137
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
抗体名: | Anti-TNFRSF10C Antibody |
抗体コード: | CAB1137 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-130 of human TNFRSF10C (NP_003832.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | LO2, Mouse lung, Rat lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-130 of human TNFRSF10C (NP_003832.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RQEE VPQQ TVAP QQQR HSFK GEEC PAGS HRSE HTGA CNPC TEGV DYTN ASNN EPSC FPCT VCKS DQKH KSSC TMTR DTVC QCKE GTFR NENS PEMC RKCS R |
遺伝子ID: | 8794 |
Uniprot: | O14798 |
セルラーロケーション: | Cell membrane, GPI-anchor, Lipid-anchor |
計算された分子量: | 27kDa |
観察された分子量: | 27kDa |
同義語: | TNFRSF10C, CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID |
バックグラウンド: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. |
UniProt Protein Function: | TRAIL-R3: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart. |
UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 8p22-p21 Cellular Component: integral to plasma membrane Molecular Function:transmembrane receptor activity; TRAIL binding Biological Process: apoptosis; signal transduction |
NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008] |
UniProt Code: | O14798 |
NCBI GenInfo Identifier: | 269849734 |
NCBI Gene ID: | 8794 |
NCBI Accession: | O14798.3 |
UniProt Secondary Accession: | O14798,O14755, Q08AS6, Q6FH98, Q6UXM5, |
UniProt Related Accession: | O14798 |
Molecular Weight: | 259 |
NCBI Full Name: | Tumor necrosis factor receptor superfamily member 10C |
NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain |
NCBI Official Symbol: | TNFRSF10C |
NCBI Official Synonym Symbols: | LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR |
NCBI Protein Information: | tumor necrosis factor receptor superfamily member 10C; decoy receptor 1; cytotoxic TRAIL receptor-3; lymphocyte inhibitor of TRAIL; decoy TRAIL receptor without death domain; antagonist decoy receptor for TRAIL/Apo-2L; TNF-related apoptosis-inducing ligan |
UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 10C |
UniProt Synonym Protein Names: | Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD_antigen: CD263 |
Protein Family: | Protein |
UniProt Gene Name: | TNFRSF10C |
UniProt Entry Name: | TR10C_HUMAN |
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