Anti-TMEM59 Antibody (CAB16089)
- SKU:
- CAB16089
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
抗体名: | Anti-TMEM59 Antibody |
抗体コード: | CAB16089 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-230 of human TMEM59 (NP_004863.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | U-87MG, A-549 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-230 of human TMEM59 (NP_004863.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | EAFD SVLG DTAS CHRA CQLT YPLH TYPK EEEL YACQ RGCR LFSI CQFV DDGI DLNR TKLE CESA CTEA YSQS DEQY ACHL GCQN QLPF AELR QEQL MSLM PKMH LLFP LTLV RSFW SDMM DSAQ SFIT SSWT FYLQ ADDG KIVI FQSK PEIQ YAPH LEQE PTNL RESS LSKM SYLQ MRNS QAHR NFLE DGES DGF |
遺伝子ID: | 9528 |
Uniprot: | Q9BXS4 |
セルラーロケーション: | Cell membrane, Golgi apparatus membrane, Late endosome membrane, Lysosome membrane, Single-pass type I membrane protein |
計算された分子量: | 36kDa |
観察された分子量: | 37KDa |
同義語: | TMEM59, C1orf8, DCF1, HSPC001, PRO195, UNQ169 |
バックグラウンド: | This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). |
NCBI Summary: | This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
UniProt Code: | Q9BXS4 |
NCBI GenInfo Identifier: | 758818592 |
NCBI Gene ID: | 9528 |
NCBI Accession: | NP_001291972.1 |
UniProt Secondary Accession: | Q9BXS4,O75393, Q4VBP9, Q5T705, Q96KX7, B3KQL7, |
UniProt Related Accession: | Q9BXS4 |
Molecular Weight: | 36,223 Da |
NCBI Full Name: | transmembrane protein 59 isoform 1 |
NCBI Synonym Full Names: | transmembrane protein 59 |
NCBI Official Symbol: | TMEM59 |
NCBI Official Synonym Symbols: | DCF1; C1orf8; PRO195; UNQ169; HSPC001 |
NCBI Protein Information: | transmembrane protein 59 |
UniProt Protein Name: | Transmembrane protein 59 |
UniProt Synonym Protein Names: | Liver membrane-bound protein |
Protein Family: | Transmembrane protein |
UniProt Gene Name: | TMEM59 |
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