Anti-TM2D1 Antibody (CAB7840)
- SKU:
- CAB7840
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
抗体名: | Anti-TM2D1 Antibody |
抗体コード: | CAB7840 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 38-207 of human TM2D1 (NP_114416.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | NCI-H460, HeLa, Mouse kidney, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 38-207 of human TM2D1 (NP_114416.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | TSAG GEES LKCE DLKV GQYI CKDP KIND ATQE PVNC TNYT AHVS CFPA PNIT CKDS SGNE THFT GNEV GFFK PISC RNVN GYSY KVAV ALSL FLGW LGAD RFYL GYPA LGLL KFCT VGFC GIGS LIDF ILIS MQIV GPSD GSSY IIDY YGTR LTRL SITN ETFR KTQL YP |
遺伝子ID: | 83941 |
Uniprot: | Q9BX74 |
セルラーロケーション: | Membrane, Multi-pass membrane protein |
計算された分子量: | 22kDa |
観察された分子量: | 30kDa |
同義語: | TM2D1, BBP |
バックグラウンド: | The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene. |
UniProt Protein Function: | TM2D1: May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42. Belongs to the TM2 family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: nucleoplasm; integral to plasma membrane Molecular Function:G-protein coupled receptor activity; beta-amyloid binding Biological Process: G-protein coupled receptor protein signaling pathway |
UniProt Code: | Q9BX74 |
NCBI GenInfo Identifier: | 14042945 |
NCBI Gene ID: | |
NCBI Accession: | NP_114416.1 |
Molecular Weight: | ~ 22kDa |
NCBI Full Name: | TM2 domain-containing protein 1 |
UniProt Protein Name: | TM2 domain-containing protein 1 |
UniProt Synonym Protein Names: | Beta-amyloid-binding protein; hBBP |
Protein Family: | Branchpoint-bridging protein |
UniProt Gene Name: | TM2D1 |
UniProt Entry Name: | TM2D1_HUMAN |
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