Anti-TDO2 Antibody (CAB13182)
- SKU:
- CAB13182
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-TDO2 Antibody |
抗体コード: | CAB13182 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-260 of human TDO2 (NP_005642.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | LO2, U-87MG, Mouse uterus, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-260 of human TDO2 (NP_005642.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | EGSE EDKS QTGV NRAS KGGL IYGN YLHL EKVL NAQE LQSE TKGN KIHD EHLF IITH QAYE LWFK QILW ELDS VREI FQNG HVRD ERNM LKVV SRMH RVSV ILKL LVQQ FSIL ETMT ALDF NDFR EYLS PASG FQSL QFRL LENK IGVL QNMR VPYN RRHY RDNF KGEE NELL LKSE QEKT LLEL VEAW LERT PGLE PHGF NFWG KLEK NITR GLEE EFIR IQAK EESE EKEE QVAE FQKQ |
遺伝子ID: | 6999 |
Uniprot: | P48775 |
セルラーロケーション: | |
計算された分子量: | 47kDa |
観察された分子量: | 47kDa |
同義語: | TDO2, TDO, TO, TPH2, TRPO, tryptophan 2 |
バックグラウンド: | This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. |
UniProt Protein Function: | TDO2: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. Belongs to the tryptophan 2,3-dioxygenase family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - tryptophan; Oxidoreductase; EC 1.13.11.11 Chromosomal Location of Human Ortholog: 4q31-q32 Cellular Component: cytosol Molecular Function:heme binding; protein binding; tryptophan 2,3-dioxygenase activity Biological Process: tryptophan catabolic process; tryptophan catabolic process to acetyl-CoA |
NCBI Summary: | This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012] |
UniProt Code: | P48775 |
NCBI GenInfo Identifier: | 1351188 |
NCBI Gene ID: | 6999 |
NCBI Accession: | P48775.1 |
UniProt Secondary Accession: | P48775,A8K053, |
UniProt Related Accession: | P48775 |
Molecular Weight: | 47,872 Da |
NCBI Full Name: | Tryptophan 2,3-dioxygenase |
NCBI Synonym Full Names: | tryptophan 2,3-dioxygenase |
NCBI Official Symbol: | TDO2 |
NCBI Official Synonym Symbols: | TO; TDO; TPH2; TRPO |
NCBI Protein Information: | tryptophan 2,3-dioxygenase |
UniProt Protein Name: | Tryptophan 2,3-dioxygenase |
UniProt Synonym Protein Names: | Tryptamin 2,3-dioxygenase |
UniProt Gene Name: | TDO2 |
UniProt Entry Name: | T23O_HUMAN |
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