Anti-TBX21 Antibody (CAB4682)

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SKU:
CAB4682
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TBX21
Synonyms:
T-PET
Synonyms:
T-bet
Synonyms:
TBET
Synonyms:
TBLYM
Synonyms:
T-box 21
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Description

抗体名:TBX21 Rabbit pAb
抗体コード:CAB4682
サイズ:20uL, 50uL, 100uL
同義語:TBX21, T-PET, T-bet, TBET, TBLYM, T-box 21
申し込み:WB
反応性:Human, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human TBX21 (NP_037483.1).
申し込み:WB
推奨される希釈:WB 1:500 - 1:1000
反応性:Human, Rat
ポジティブサンプル:B cells
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human TBX21 (NP_037483.1).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:ENFE SMYT SVDT SIPS PPGP NCQF LGGD HYSP LLPN QYPV PSRF YPDL PGQA KDVV PQAY WLGA PRDH SYEA EFRA VSMK PAFL PSAP GPTM SYYR GQEV LAPG AGWP VAPQ YPPK MGPA SWFR PMRT LPME PGPG GSEG RGPE DQGP PLVW TEIA PIRP ESSD SGLG EGDS KRRR VSPY PSSG DSSS PAGA PSPF DKEA EGQF YNYF PN
遺伝子ID:30009
Uniprot:Q9UL17
セルラーロケーション:Nucleus
計算された分子量:58kDa
観察された分子量:58kDa
UniProt Protein Function:TBX21: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cell soma; nucleus

Molecular Function:transcription factor activity

Biological Process: positive regulation of isotype switching to IgG isotypes; transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to virus; positive regulation of transcription, DNA-dependent; multicellular organismal development; T cell differentiation

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance

NCBI Summary:This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UL17
NCBI GenInfo Identifier:12230772
NCBI Gene ID:30009
NCBI Accession:Q9UL17.1
UniProt Related Accession:Q9UL17
Molecular Weight:58,328 Da
NCBI Full Name:T-box transcription factor TBX21
NCBI Synonym Full Names:T-box 21
NCBI Official Symbol:TBX21  
NCBI Official Synonym Symbols:TBET; T-PET; T-bet; TBLYM  
NCBI Protein Information:T-box transcription factor TBX21; T-box protein 21; T-box expressed in T cells; transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet
UniProt Protein Name:T-box transcription factor TBX21
UniProt Synonym Protein Names:T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM
Protein Family:T-box transcription factor
UniProt Gene Name:TBX21  
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