Anti-TBL1XR1 Monoclonal Antibody (CAB9922)
- SKU:
- CAB9922
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Application:
- ICC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Mouse
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-TBL1XR1 Monoclonal Antibody |
| 抗体コード: | CAB9922 |
| 抗体サイズ: | 100µL |
| 申し込み: | WB IHC ICC |
| 反応性: | Human, Mouse |
| 宿主種: | Mouse |
| 免疫原: | Recombinant protein of human TBL1XR1 |
| 申し込み: | WB IHC ICC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 ICC 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | K-562, 293T, HeLa, NIH/3T3, HT-1080, THP-1 |
| 免疫原: | Recombinant protein of human TBL1XR1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 79718 |
| Uniprot: | Q9BZK7 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 55kDa |
| 観察された分子量: | 55kDa |
| 同義語: | TBL1XR1, C21, DC42, IRA1, MRD41, TBLR1 |
| バックグラウンド: | This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. |
| UniProt Protein Function: | TBL1XR1: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4. Ubiquitous. Belongs to the WD repeat EBI family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 3q26.32 Cellular Component: nucleoplasm; transcriptional repressor complex; spindle microtubule; histone deacetylase complex; nucleus Molecular Function:protein binding; histone binding; beta-catenin binding; protein N-terminus binding; transcription corepressor activity Biological Process: proteasomal ubiquitin-dependent protein catabolic process; establishment and/or maintenance of chromatin architecture; Notch signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; histone deacetylation; Wnt receptor signaling pathway through beta-catenin; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BZK7 |
| NCBI GenInfo Identifier: | 23396874 |
| NCBI Gene ID: | 79718 |
| NCBI Accession: | Q9BZK7.1 |
| UniProt Secondary Accession: | Q9BZK7,Q14DC3, Q9H2I1, Q9H9A1, D3DNQ9, |
| UniProt Related Accession: | Q9BZK7 |
| Molecular Weight: | 55,595 Da |
| NCBI Full Name: | F-box-like/WD repeat-containing protein TBL1XR1 |
| NCBI Synonym Full Names: | transducin (beta)-like 1 X-linked receptor 1 |
| NCBI Official Symbol: | TBL1XR1 |
| NCBI Official Synonym Symbols: | C21; DC42; IRA1; TBLR1 |
| NCBI Protein Information: | F-box-like/WD repeat-containing protein TBL1XR1; TBL1-related protein 1; transducin beta-like 1X-related protein 1; nuclear receptor co-repressor/HDAC3 complex subunit; nuclear receptor corepressor/HDAC3 complex subunit TBLR1 |
| UniProt Protein Name: | F-box-like/WD repeat-containing protein TBL1XR1 |
| UniProt Synonym Protein Names: | Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1 |
| Protein Family: | F-box-like/WD repeat-containing protein |
| UniProt Gene Name: | TBL1XR1 |
| UniProt Entry Name: | TBL1R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TBL1XR1 antibody (CAB9922) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Mouse IgG (H+L) (CABS003) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 20s. |
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