Anti-SYVN1 Antibody (CAB2605)
- SKU:
- CAB2605
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-SYVN1 Antibody |
抗体コード: | CAB2605 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human SYVN1 (NP_757385.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa, HepG2, Mouse pancreas, Mouse lung, Mouse kidney |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human SYVN1 (NP_757385.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LEAR LQSL RNIH TLLD AAML QINQ YLTV LASL GPPR PATS VNST EETA TTVV AAAS STSI PSSE ATTP TPGA SPPA PEME RPPA PESV GTEE MPED GEPD AAEL RRRR LQKL ESPV AH |
遺伝子ID: | 84447 |
Uniprot: | Q86TM6 |
セルラーロケーション: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
計算された分子量: | 61kDa/67kDa |
観察された分子量: | 70kDa |
同義語: | SYVN1, DER3, HRD1 |
バックグラウンド: | This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. |
UniProt Protein Function: | SYVN1: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Belongs to the HRD1 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; EC 6.3.2.-; Endoplasmic reticulum; Ligase; Ubiquitin ligase; Membrane protein, multi-pass; EC 6.3.2.19; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane Molecular Function:protein binding; acid-amino acid ligase activity; zinc ion binding Biological Process: ER-associated protein catabolic process; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response; in utero embryonic development; protein ubiquitination; protein amino acid N-linked glycosylation via asparagine |
NCBI Summary: | This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011] |
UniProt Code: | Q86TM6 |
NCBI GenInfo Identifier: | 134035039 |
NCBI Gene ID: | 84447 |
NCBI Accession: | Q86TM6.2 |
UniProt Secondary Accession: | Q86TM6,Q8N3K3, Q8N6E8, Q96JL5, Q96PK3, |
UniProt Related Accession: | Q86TM6 |
Molecular Weight: | 617 |
NCBI Full Name: | E3 ubiquitin-protein ligase synoviolin |
NCBI Synonym Full Names: | synovial apoptosis inhibitor 1, synoviolin |
NCBI Official Symbol: | SYVN1 |
NCBI Official Synonym Symbols: | DER3; HRD1 |
NCBI Protein Information: | E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog |
UniProt Protein Name: | E3 ubiquitin-protein ligase synoviolin |
UniProt Synonym Protein Names: | Synovial apoptosis inhibitor 1 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | SYVN1 |
UniProt Entry Name: | SYVN1_HUMAN |
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