Anti-Survivin Antibody (CAB4838)
- SKU:
- CAB4838
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- API4
- Synonyms:
- EPR-1
Description
| 抗体名: | Survivin Rabbit mAb |
| 抗体コード: | CAB4838 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | API4, EPR-1 |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human Survivin |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse spleen, Mouse thymus, Rat testis |
| 免疫原: | A synthesized peptide derived from human Survivin |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 332 |
| Uniprot: | O15392 |
| セルラーロケーション: | Chromosome, Cytoplasm, Midbody, Nucleus, centromere, cytoskeleton, kinetochore, spindle |
| 計算された分子量: | 16kDa |
| 観察された分子量: | 18KDa |
| UniProt Protein Function: | Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 17q25 Cellular Component: centriole; nuclear chromosome; microtubule; spindle microtubule; cytoplasmic microtubule; cytoplasm; spindle; midbody; interphase microtubule organizing center; nucleus; cytosol; chromosome, pericentric region Molecular Function:tubulin binding; identical protein binding; protein homodimerization activity; zinc ion binding; microtubule binding; metal ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; protein binding; enzyme binding; protein heterodimerization activity; chaperone binding; cofactor binding; cysteine protease inhibitor activity; Ran GTPase binding; cobalt ion binding Biological Process: mitosis; transcription, DNA-dependent; spindle checkpoint; establishment of chromosome localization; regulation of signal transduction; protein ubiquitination; cytokinesis; negative regulation of caspase activity; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; chromosome segregation; protein complex localization; cell division; positive regulation of cell proliferation; mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; positive regulation of exit from mitosis |
| NCBI Summary: | This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
| UniProt Code: | O15392 |
| NCBI GenInfo Identifier: | 380865472 |
| NCBI Gene ID: | 332 |
| NCBI Accession: | O15392.3 |
| UniProt Secondary Accession: | O15392,Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2 Q9P2W8, A2SUH6, B2R4R1, |
| UniProt Related Accession: | O15392 |
| Molecular Weight: | 8,490 Da |
| NCBI Full Name: | Baculoviral IAP repeat-containing protein 5 |
| NCBI Synonym Full Names: | baculoviral IAP repeat containing 5 |
| NCBI Official Symbol: | BIRC5 |
| NCBI Official Synonym Symbols: | API4; EPR-1 |
| NCBI Protein Information: | baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin |
| UniProt Protein Name: | Baculoviral IAP repeat-containing protein 5 |
| UniProt Synonym Protein Names: | Apoptosis inhibitor 4; Apoptosis inhibitor survivin |
| Protein Family: | Baculoviral IAP repeat-containing protein |
| UniProt Gene Name: | BIRC5 |
| UniProt Entry Name: | BIRC5_HUMAN |
Related Products
