Anti-SUPT4H1 Antibody (CAB7933)
- SKU:
- CAB7933
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-SUPT4H1 Antibody |
抗体コード: | CAB7933 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-117 of human SUPT4H1 (NP_003159.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | MCF7, B cells |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-117 of human SUPT4H1 (NP_003159.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MALE TVPK DLRH LRAC LLCS LVKT IDQF EYDG CDNC DAYL QMKG NREM VYDC TSSS FDGI IAMM SPED SWVS KWQR VSNF KPGV YAVS VTGR LPQG IVRE LKSR GVAY KSRD TAIK T |
遺伝子ID: | 6827 |
Uniprot: | P63272 |
セルラーロケーション: | Nucleus |
計算された分子量: | 13kDa |
観察された分子量: | 14kDa |
同義語: | SUPT4H1, SPT4, SPT4H, SUPT4H, Supt4a |
バックグラウンド: | This gene encodes the small subunit of DRB (5, 6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. |
UniProt Protein Function: | Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences. |
NCBI Summary: | This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012] |
UniProt Code: | P63272 |
NCBI GenInfo Identifier: | 4507311 |
NCBI Gene ID: | 6827 |
NCBI Accession: | NP_003159.1 |
UniProt Secondary Accession: | P63272,Q16550, Q62387, Q6ZP89, B2R4X8, D3DTZ4, |
UniProt Related Accession: | P63272 |
Molecular Weight: | 12 |
NCBI Full Name: | transcription elongation factor SPT4 |
NCBI Synonym Full Names: | SPT4 homolog, DSIF elongation factor subunit |
NCBI Official Symbol: | SUPT4H1 |
NCBI Official Synonym Symbols: | SPT4; SPT4H; SUPT4H; Supt4a |
NCBI Protein Information: | transcription elongation factor SPT4 |
UniProt Protein Name: | Transcription elongation factor SPT4 |
UniProt Synonym Protein Names: | DRB sensitivity-inducing factor 14 kDa subunit; DSIF p14; DRB sensitivity-inducing factor small subunit; DSIF small subunit |
UniProt Gene Name: | SUPT4H1 |
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