Anti-SUMO3 Antibody (CAB15724)
- SKU:
- CAB15724
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-SUMO3 Antibody |
抗体コード: | CAB15724 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human SUMO3 (NP_008867.2). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, LO2, 293T, Mouse liver, Mouse kidney, Mouse small intestine, Mouse heart, Rat liver, Rat heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-92 of human SUMO3 (NP_008867.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSEE KPKE GVKT ENDH INLK VAGQ DGSV VQFK IKRH TPLS KLMK AYCE RQGL SMRQ IRFR FDGQ PINE TDTP AQLE MEDE DTID VFQQ QTGG |
遺伝子ID: | 6612 |
Uniprot: | P55854 |
セルラーロケーション: | Cytoplasm, Nucleus, PML body |
計算された分子量: | 11kDa/15kDa |
観察された分子量: | 17-50kDa |
同義語: | SUMO3, SMT3A, SMT3H1, SUMO-3, Smt3B |
バックグラウンド: | This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. |
UniProt Protein Function: | SUMO3: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I. Expressed predominantly in liver. Belongs to the ubiquitin family. SUMO subfamily. |
UniProt Protein Details: | Protein type:Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: kinetochore; nucleoplasm; PML body; cytoplasm; nucleus Molecular Function:protein binding; SUMO ligase activity Biological Process: cellular protein metabolic process; protein sumoylation; post-translational protein modification |
NCBI Summary: | This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014] |
UniProt Code: | P55854 |
NCBI GenInfo Identifier: | 23503102 |
NCBI Gene ID: | 6612 |
NCBI Accession: | P55854.2 |
UniProt Related Accession: | P55854 |
Molecular Weight: | |
NCBI Full Name: | Small ubiquitin-related modifier 3 |
NCBI Synonym Full Names: | small ubiquitin like modifier 3 |
NCBI Official Symbol: | SUMO3 |
NCBI Official Synonym Symbols: | SMT3A; Smt3B; SMT3H1; SUMO-3 |
NCBI Protein Information: | small ubiquitin-related modifier 3 |
UniProt Protein Name: | Small ubiquitin-related modifier 3 |
UniProt Synonym Protein Names: | SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3A |
UniProt Gene Name: | SUMO3 |
UniProt Entry Name: | SUMO3_HUMAN |
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