Anti-SUCLA2 Antibody (CAB10040)
- SKU:
- CAB10040
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-SUCLA2 Antibody |
抗体コード: | CAB10040 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SUCLA2 (NP_003841.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:1000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T, SW480, HeLa, Mouse heart, Mouse liver, Mouse brain, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SUCLA2 (NP_003841.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAAS MFYG RLVA VATL RNHR PRTA QRAA AQVL GSSG LFNN HGLQ VQQQ QQRN LSLH EYMS MELL QEAG VSVP KGYV AKSP DEAY AIAK KLGS KDVV IKAQ VLAG GRGK GTFE SGLK GGVK IVFS PEEA KAVS SQMI GKKL FTKQ TGEK GRIC NQVL VCER KYPR REYY FAIT MERS FQGP |
遺伝子ID: | 8803 |
Uniprot: | Q9P2R7 |
セルラーロケーション: | Mitochondrion |
計算された分子量: | 48kDa/50kDa |
観察された分子量: | 50kDa |
同義語: | SUCLA2, A-BETA, A-SCS, MTDPS5, SCS-betaA |
バックグラウンド: | Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. |
UniProt Protein Function: | SCS-beta: a mitochondrial enzyme that catalyzes the phosphorylation of NTP, where N = adenosine or guanosine, in the tricarboxylic acid cycle. Catalyzes the following: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. Two splice variant isoforms have been described. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; EC 6.2.1.5; Carbohydrate Metabolism - propanoate; Ligase Chromosomal Location of Human Ortholog: 13q14.2 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:protein binding; metal ion binding; succinate-CoA ligase (ADP-forming) activity; ATP binding Biological Process: succinate metabolic process; cellular metabolic process; succinyl-CoA pathway; succinyl-CoA metabolic process; tricarboxylic acid cycle Disease: Mitochondrial Dna Depletion Syndrome 5 (encephalomyopathic With Or Without Methylmalonic Aciduria) |
NCBI Summary: | Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9P2R7 |
NCBI GenInfo Identifier: | 94730427 |
NCBI Gene ID: | 8803 |
NCBI Accession: | Q9P2R7.3 |
UniProt Secondary Accession: | Q9P2R7,O95194, Q5T9Q4, Q5T9Q6, Q9NV21, Q9NVP7, B2RDE7 |
UniProt Related Accession: | Q9P2R7 |
Molecular Weight: | 48,040 Da |
NCBI Full Name: | Succinyl-CoA ligase |
NCBI Synonym Full Names: | succinate-CoA ligase, ADP-forming, beta subunit |
NCBI Official Symbol: | SUCLA2 |
NCBI Official Synonym Symbols: | A-BETA; MTDPS5; SCS-betaA |
NCBI Protein Information: | succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial |
UniProt Protein Name: | Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial |
UniProt Synonym Protein Names: | ATP-specific succinyl-CoA synthetase subunit beta; Renal carcinoma antigen NY-REN-39; Succinyl-CoA synthetase beta-A chain; SCS-betaA |
UniProt Gene Name: | SUCLA2 |
UniProt Entry Name: | SUCB1_HUMAN |
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