Anti-STK10 Antibody (CAB14257)
- SKU:
- CAB14257
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
抗体名: | Anti-STK10 Antibody |
抗体コード: | CAB14257 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-510 of human STK10 (NP_005981.3). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | K-562, U-87MG, HT-29, 293T |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-510 of human STK10 (NP_005981.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | DGRD EGEE EDAV DAAS TLEN HTQN SSEV SPPS LNAD KPLE ESPS TPLA PSQS QDSV NEPC SQPS GDRS LQTT SPPV VAPG NENG LAVP VPLR KSRP VSMD ARIQ VAQE KQVA EQGG DLSP AANR SQKA SQSR PNSS ALET LGGE KLAN GSLE PPAQ AAPG PSKR DSDC SSLC TSES MDYG TNLS TDLS LNK |
遺伝子ID: | 6793 |
Uniprot: | O94804 |
セルラーロケーション: | Cell membrane, Peripheral membrane protein |
計算された分子量: | 112kDa |
観察された分子量: | 140kDa |
同義語: | STK10, LOK, PRO2729 |
バックグラウンド: | This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. |
UniProt Protein Function: | LOK: a protein kinase of the STE20 family. Highly expressed in hematopoietic tissue. May cooperate with SLK to regulate Plk1 function in human cells. |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; SLK subfamily Chromosomal Location of Human Ortholog: 5q35.1 Cellular Component: cytoplasm; plasma membrane Molecular Function:identical protein binding; polo kinase kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activity Biological Process: protein amino acid autophosphorylation; protein amino acid phosphorylation |
NCBI Summary: | This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008] |
UniProt Code: | O94804 |
NCBI GenInfo Identifier: | 12643358 |
NCBI Gene ID: | 6793 |
NCBI Accession: | O94804.1 |
UniProt Secondary Accession: | O94804,Q6NSK0, Q9UIW4, A6ND35, B2R8F5, B3KMY1, |
UniProt Related Accession: | O94804 |
Molecular Weight: | 112,135 Da |
NCBI Full Name: | Serine/threonine-protein kinase 10 |
NCBI Synonym Full Names: | serine/threonine kinase 10 |
NCBI Official Symbol: | STK10 |
NCBI Official Synonym Symbols: | LOK; PRO2729 |
NCBI Protein Information: | serine/threonine-protein kinase 10 |
UniProt Protein Name: | Serine/threonine-protein kinase 10 |
UniProt Synonym Protein Names: | Lymphocyte-oriented kinase |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | STK10 |
UniProt Entry Name: | STK10_HUMAN |
View AllClose