Anti-STAU1 Antibody (CAB4131)
- SKU:
- CAB4131
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-STAU1 Antibody |
抗体コード: | CAB4131 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 426-577 of human STAU1 (NP_059347.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SW480, BT-474, K-562, Mouse liver, Mouse brain, Rat liver, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 426-577 of human STAU1 (NP_059347.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | QAVG VSQG HHTK DFTR AAPN PAKA TVTA MIAR ELLY GGTS PTAE TILK NNIS SGHV PHGP LTRP SEQL DYLS RVQG FQVE YKDF PKNN KNEF VSLI NCSS QPPL ISHG IGKD VESC HDMA ALNI LKLL SELD QQST EMPR TGNG PMSV CGRC |
遺伝子ID: | 6780 |
Uniprot: | O95793 |
セルラーロケーション: | Cytoplasm, Rough endoplasmic reticulum |
計算された分子量: | 54kDa/55kDa/63kDa |
観察された分子量: | 58kDa |
同義語: | STAU1, PPP1R150, STAU |
バックグラウンド: | Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. |
UniProt Protein Function: | STAU: Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 20q13.1 Cellular Component: microtubule associated complex; cell soma; rough endoplasmic reticulum; membrane; endoplasmic reticulum; stress granule; dendrite; cytoplasm Molecular Function:protein binding; double-stranded RNA binding; protein phosphatase 1 binding Biological Process: intracellular mRNA localization; positive regulation of viral genome replication; positive regulation of viral protein levels in host cell |
UniProt Code: | O95793 |
NCBI GenInfo Identifier: | 90185286 |
NCBI Gene ID: | |
NCBI Accession: | O95793.2 |
Molecular Weight: | 55kDa |
NCBI Full Name: | Double-stranded RNA-binding protein Staufen homolog 1 |
UniProt Protein Name: | Double-stranded RNA-binding protein Staufen homolog 1 |
Protein Family: | Maternal effect protein staufen |
UniProt Gene Name: | STAU1 |
UniProt Entry Name: | STAU1_HUMAN |
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