Anti-STAMBP Antibody (CAB7065)
- SKU:
- CAB7065
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-STAMBP Antibody |
抗体コード: | CAB7065 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-270 of human STAMBP (NP_998787.1). |
申し込み: | WB IHC IF IP |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 IP 1:20 - 1:50 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | MCF7, SW480, HepG2, HeLa, 293T, Mouse brain, Rat lung, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-270 of human STAMBP (NP_998787.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | FPKA EELK AELL KRYT KEYT EYNE EKKK EAEE LARN MAIQ QELE KEKQ RVAQ QKQQ QLEQ EQFH AFEE MIRN QELE KERL KIVQ EFGK VDPG LGGP LVPD LEKP SLDV FPTL TVSS IQPS DCHT TVRP AKPP VVDR SLKP GALS NSES IPTI DGLR HVVV PGRL CPQF LQL |
遺伝子ID: | 10617 |
Uniprot: | O95630 |
セルラーロケーション: | Cytoplasm, Early endosome, Membrane, Nucleus, Peripheral membrane protein |
計算された分子量: | 39kDa/48kDa |
観察された分子量: | 48kDa |
同義語: | STAMBP, AMSH, MICCAP |
バックグラウンド: | Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. |
UniProt Protein Function: | AMSH: an adaptor protein involved in cytokine signal transduction the JAK-STAT cascade. Binds to the SH3 domain of the signal-transducing adaptor molecule STAM (signal transducing adaptor molecule). May play a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. |
UniProt Protein Details: | Protein type:EC 3.1.2.15; Protease; Ubiquitin-specific protease; EC 3.4.19.- Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: cleavage furrow; cytoplasm; nucleoplasm; nucleus; plasma membrane Molecular Function:protein binding; protein domain specific binding; ubiquitin-specific protease activity Biological Process: cytokinesis after mitosis; JAK-STAT cascade; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of Ras protein signal transduction; positive regulation of cell proliferation; protein deubiquitination Disease: Microcephaly-capillary Malformation Syndrome |
NCBI Summary: | Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95630 |
NCBI GenInfo Identifier: | 71153538 |
NCBI Gene ID: | 10617 |
NCBI Accession: | O95630.1 |
UniProt Secondary Accession: | O95630,Q3MJE7, B5M0B6, D6W5H7, |
UniProt Related Accession: | O95630 |
Molecular Weight: | 39,596 Da |
NCBI Full Name: | STAM-binding protein |
NCBI Synonym Full Names: | STAM binding protein |
NCBI Official Symbol: | STAMBP |
NCBI Official Synonym Symbols: | AMSH; MICCAP |
NCBI Protein Information: | STAM-binding protein |
UniProt Protein Name: | STAM-binding protein |
UniProt Synonym Protein Names: | Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase |
Protein Family: | STAM-binding protein |
UniProt Gene Name: | STAMBP |
UniProt Entry Name: | STABP_HUMAN |
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