Anti-SLC5A5 Antibody (CAB9605)
- SKU:
- CAB9605
- Product type:
- Antibody
- Application:
- WB
- Application:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-SLC5A5 Antibody |
抗体コード: | CAB9605 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 544-643 of human SLC5A5 (NP_000444.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:20 - 1:50 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | THP-1, SGC-7901 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 544-643 of human SLC5A5 (NP_000444.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ALIS CLTG PTKR STLA PGLL WWDL ARQT ASVA PKEE VAIL DDNL VKGP EELP TGNK KPPG FLPT NEDR LFFL GQKE LEGA GSWT PCVG HDGG RDQQ ETNL |
遺伝子ID: | 6528 |
Uniprot: | Q92911 |
セルラーロケーション: | Membrane, Multi-pass membrane protein |
計算された分子量: | 68kDa |
観察された分子量: | 68kDa |
同義語: | SLC5A5, NIS, TDH1 |
バックグラウンド: | This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1. |
UniProt Protein Function: | SLC5A5: Mediates iodide uptake in the thyroid gland. Defects in SLC5A5 are the cause of thyroid dyshormonogenesis 1 (TDH1). A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: integral component of membrane; nucleus; plasma membrane Molecular Function:iodide transmembrane transporter activity; sodium:iodide symporter activity Biological Process: iodide transport; ion transport; thyroid hormone generation; transport Disease: Thyroid Dyshormonogenesis 1 |
NCBI Summary: | This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009] |
UniProt Code: | Q92911 |
NCBI GenInfo Identifier: | 4507035 |
NCBI Gene ID: | 6528 |
NCBI Accession: | NP_000444.1 |
UniProt Secondary Accession: | Q92911,O43702, Q2M335, Q9NYB6, |
UniProt Related Accession: | Q92911 |
Molecular Weight: | |
NCBI Full Name: | sodium/iodide cotransporter |
NCBI Synonym Full Names: | solute carrier family 5 member 5 |
NCBI Official Symbol: | SLC5A5 |
NCBI Official Synonym Symbols: | NIS; TDH1 |
NCBI Protein Information: | sodium/iodide cotransporter |
UniProt Protein Name: | Sodium/iodide cotransporter |
UniProt Synonym Protein Names: | Sodium-iodide symporter; Na(+)/I(-) symporter; Solute carrier family 5 member 5 |
UniProt Gene Name: | SLC5A5 |
View AllClose