Anti-SLC4A4 / NBC Antibody (CAB5332)
- SKU:
- CAB5332
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-SLC4A4 / NBC Antibody |
抗体コード: | CAB5332 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SLC4A4 / NBC (NP_003750.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | LNCaP, Mouse brain, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SLC4A4 / NBC (NP_003750.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSTE NVEG KPSN LGER GRAR SSTF LRVV QPMF NHSI FTSA VSPA AERI RFIL GEED DSPA PPQL FTEL DELL AVDG QEME WKET ARWI KFEE KVEQ GGER WSKP HVAT LSLH SLFE LRTC MEKG SIML DREA SSLP QLVE MIVD HQIE TGLL KPEL KDKV TYTL LRKH RHQT KKSN LRSL ADIG KTVS SASR MFTN PDNG SPAM THRN LTSS SLND ISDK PEKD QLKN KFMK KLPR DAEA |
遺伝子ID: | 8671 |
Uniprot: | Q9Y6R1 |
セルラーロケーション: | Basolateral cell membrane, Multi-pass membrane protein |
計算された分子量: | 72kDa/112kDa/116kDa/121kDa/123kDa |
観察された分子量: | 135KDa |
同義語: | SLC4A4, HNBC1, KNBC, NBC1, NBC2, NBCe1-A, SLC4A5, hhNMC, kNBC1, pNBC |
バックグラウンド: | This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | SLC4A4: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Defects in SLC4A4 are the cause of proximal renal tubular acidosis with ocular abnormalities (pRTA-OA); also known as renal tubular acidosis II. Caused by an impairment of bicarbonate absorption in the proximal tubule, proximal renal tubular acidosis (pRTA) is characterized by a decreased renal HCO3(-) threshold. pRTA-OA is an extremely rare autosomal recessive syndrome characterized by short stature, profound pRTA, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy. Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17). Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 4q21 Cellular Component: integral to plasma membrane; basolateral plasma membrane; plasma membrane Molecular Function:protein binding; inorganic anion exchanger activity; sodium:bicarbonate symporter activity Biological Process: transport; bicarbonate transport; regulation of intracellular pH; ion transport; transmembrane transport Disease: Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation |
NCBI Summary: | This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q9Y6R1 |
NCBI GenInfo Identifier: | 74721543 |
NCBI Gene ID: | 8671 |
NCBI Accession: | Q9Y6R1.1 |
UniProt Secondary Accession: | Q9Y6R1,O15153, Q8NEJ2, Q9H262, Q9NRZ1, Q9UIC0, Q9UIC1 Q9UP50, C4B714, |
UniProt Related Accession: | Q9Y6R1 |
Molecular Weight: | 1079 |
NCBI Full Name: | Electrogenic sodium bicarbonate cotransporter 1 |
NCBI Synonym Full Names: | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 |
NCBI Official Symbol: | SLC4A4 |
NCBI Official Synonym Symbols: | KNBC; NBC1; NBC2; pNBC; HNBC1; hhNMC; SLC4A5; NBCe1-A |
NCBI Protein Information: | electrogenic sodium bicarbonate cotransporter 1; kNBC1; Na(+)/HCO3(-) cotransporter; solute carrier family 4, sodium bicarbonate cotransporter, member 5; solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type; sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas) |
UniProt Protein Name: | Electrogenic sodium bicarbonate cotransporter 1 |
UniProt Synonym Protein Names: | Na(+)/HCO3(-) cotransporter; Solute carrier family 4 member 4; kNBC1 |
Protein Family: | Electrogenic sodium bicarbonate cotransporter |
UniProt Gene Name: | SLC4A4 |
UniProt Entry Name: | S4A4_HUMAN |
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