Anti-SLC25A15 Antibody (CAB4381)

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SKU:
CAB4381
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SLC25A15
Synonyms:
D13S327
Synonyms:
HHH
Synonyms:
ORC1
Synonyms:
ORNT1
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Description

I抗体名:SLC25A15 Rabbit pAb
抗体コード:CAB4381
サイズ:20uL, 50uL, 100uL
同義語:SLC25A15, D13S327, HHH, ORC1, ORNT1
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human SLC25A15 (NP_055067.1).
申し込み:WB
推奨される希釈:WB 1:200 - 1:2000
反応性:Human
ポジティブサンプル:HeLa, MCF7
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human SLC25A15 (NP_055067.1).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MKSN PAIQ AAID LTAG AAGG TACV LTGQ PFDT MKVK MQTF PDLY RGLT DCCL KTYS QVGF RGFY KGTS PALI ANIA ENSV LFMC YGFC QQVV RKVA GLDK QAKL SDLQ NAAA GSFA SAFA ALVL CPTE LVKC RLQT MYEM ETSG KIAK SQNT VWSV IKSI LRKD GPLG FYHG LSST LLRE VPGY FFFF GGYE LSRS FFAS GRSK DELG PVPL MLSG GVGG ICLW LAVY PVDC IKSR IQVL SMSG KQAG FIRT FINV VKNE GITA LYSG LKPT MIRA FPAN GALF LAYE YSRK LMMN QLEA Y
遺伝子ID:10166
Uniprot:Q9Y619
セルラーロケーション:Mitochondrion inner membrane, Multi-pass membrane protein
計算された分子量:32kDa
観察された分子量:35kDa
UniProt Protein Function:SLC25A15: Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix. Defects in SLC25A15 are the cause of hyperornithinemia- hyperammonemia-homocitrullinuria syndrome (HHH syndrome). It is an autosomal recessive disorder resulting in various neurologic symptoms, including mental retardation, spastic paraparesis with pyramidal signs, cerebellar ataxia, and episodic disturbance of consciousness or coma caused by hyperammonemia. It causes a functional impairment of the urea cycle. Belongs to the mitochondrial carrier family.
UniProt Protein Details:

Protein type:Transporter; Transporter, SLC family; Membrane protein, multi-pass; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: mitochondrial inner membrane; integral to membrane

Molecular Function:L-ornithine transmembrane transporter activity

Biological Process: amino acid metabolic process; mitochondrial ornithine transport; urea cycle

Disease: Hyperornithinemia-hyperammonemia-homocitrullinuria Syndrome

NCBI Summary:This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009]
UniProt Code:Q9Y619
NCBI GenInfo Identifier:20139303
NCBI Gene ID:10166
NCBI Accession:Q9Y619.1
UniProt Related Accession:Q9Y619
Molecular Weight:Predicted Molecular Mass: 36.4kDaAccurate Molecular Mass: 33kDa
NCBI Full Name:Mitochondrial ornithine transporter 1
NCBI Synonym Full Names:solute carrier family 25 member 15
NCBI Official Symbol:SLC25A15  
NCBI Official Synonym Symbols:HHH; ORC1; ORNT1; LNC-HC; D13S327  
NCBI Protein Information:mitochondrial ornithine transporter 1
UniProt Protein Name:Mitochondrial ornithine transporter 1
UniProt Synonym Protein Names:Solute carrier family 25 member 15
UniProt Gene Name:SLC25A15  
UniProt Entry Name:ORNT1_HUMAN
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