Anti-SLC1A4 Antibody (CAB12507)
- SKU:
- CAB12507
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| 抗体名: | Anti-SLC1A4 Antibody |
| 抗体コード: | CAB12507 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-220 of human SLC1A4 (NP_003029.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Raji, SW480, BT-474, Mouse brain, Mouse kidney, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-220 of human SLC1A4 (NP_003029.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KPGS GAQT LQSS DLGL EDSG PPPV PKET VDSF LDLA RNLF PSNL VVAA FRTY ATDY KVVT QNSS SGNV THEK IPIG TEIE G |
| 遺伝子ID: | 6509 |
| Uniprot: | P43007 |
| セルラーロケーション: | Melanosome, Membrane, Multi-pass membrane protein |
| 計算された分子量: | 24kDa/55kDa |
| 観察された分子量: | 53kDa |
| 同義語: | SLC1A4, ASCT1, SATT, SPATCCM |
| バックグラウンド: | The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. |
| UniProt Protein Function: | SLC1A4: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral Chromosomal Location of Human Ortholog: 2p15-p13 Cellular Component: centrosome; cell surface; cell soma; membrane; integral to plasma membrane; dendrite; melanosome; integral to membrane; plasma membrane; intermediate filament; microtubule organizing center Molecular Function:L-serine transmembrane transporter activity; chloride channel activity; L-threonine transmembrane transporter activity; L-proline transmembrane transporter activity; L-alanine transmembrane transporter activity; L-glutamine transmembrane transporter activity; L-cystine transmembrane transporter activity; sodium:dicarboxylate symporter activity Biological Process: synaptic transmission, glutamatergic; threonine transport; L-cystine transport; chloride transport; L-serine transport; L-alanine transport; dicarboxylic acid transport; amino acid transport; ion transport; cognition; proline transport; glutamine transport; transmembrane transport |
| NCBI Summary: | The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. [provided by RefSeq, Jan 2017] |
| UniProt Code: | P43007 |
| NCBI GenInfo Identifier: | 1173365 |
| NCBI Gene ID: | 6509 |
| NCBI Accession: | P43007.1 |
| UniProt Related Accession: | P43007 |
| Molecular Weight: | ~56kDa |
| NCBI Full Name: | Neutral amino acid transporter A |
| NCBI Synonym Full Names: | solute carrier family 1 member 4 |
| NCBI Official Symbol: | SLC1A4 |
| NCBI Official Synonym Symbols: | SATT; ASCT1; SPATCCM |
| NCBI Protein Information: | neutral amino acid transporter A |
| UniProt Protein Name: | Neutral amino acid transporter A |
| UniProt Synonym Protein Names: | Alanine/serine/cysteine/threonine transporter 1; ASCT-1; SATT; Solute carrier family 1 member 4 |
| Protein Family: | Neutral amino acid transporter |
| UniProt Gene Name: | SLC1A4 |
| UniProt Entry Name: | SATT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC1A4 antibody (CAB12507) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded rat brain using SLC1A4 antibody (CAB12507) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using SLC1A4 antibody (CAB12507) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spinal cord using SLC1A4 antibody (CAB12507) at dilution of 1:100 (40x lens). |
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