Anti-SLC1A2 Antibody (CAB0910)
- SKU:
- CAB0910
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-SLC1A2 Antibody |
抗体コード: | CAB0910 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 495-574 of human SLC1A2 (NP_004162.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:5000 IHC 1:100 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | MCF7, HepG2, SW480, Mouse liver, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 495-574 of human SLC1A2 (NP_004162.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | HLSK SELD TIDS QHRV HEDI EMTK TQSI YDDM KNHR ESNS NQCV YAAH NSVI VDEC KVTL AANG KSAD CSVE EEPW KREK |
遺伝子ID: | 6506 |
Uniprot: | P43004 |
セルラーロケーション: | Membrane, Multi-pass membrane protein |
計算された分子量: | 61kDa/62kDa |
観察された分子量: | 65kDa |
同義語: | SLC1A2, EAAT2, EIEE41, GLT-1, HBGT |
バックグラウンド: | This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. |
UniProt Protein Function: | Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. |
NCBI Summary: | This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010] |
UniProt Code: | P43004 |
NCBI GenInfo Identifier: | 3041668 |
NCBI Gene ID: | 6506 |
NCBI Accession: | P43004.2 |
UniProt Secondary Accession: | P43004,Q14417, Q541G6, B4DQE9, U3KQQ4, |
UniProt Related Accession: | P43004 |
Molecular Weight: | 61,008 Da |
NCBI Full Name: | Excitatory amino acid transporter 2 |
NCBI Synonym Full Names: | solute carrier family 1 member 2 |
NCBI Official Symbol: | SLC1A2 |
NCBI Official Synonym Symbols: | HBGT; EAAT2; GLT-1 |
NCBI Protein Information: | excitatory amino acid transporter 2 |
UniProt Protein Name: | Excitatory amino acid transporter 2 |
UniProt Synonym Protein Names: | Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 |
Protein Family: | Excitatory amino acid transporter |
UniProt Gene Name: | SLC1A2 |
UniProt Entry Name: | EAA2_HUMAN |
View AllClose